{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:37:09Z","timestamp":1781811429090,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Electromagnetic navigation bronchoscopy (ENB)\u2010guided pleural dye marking is useful to localize small peripheral pulmonary nodules for sublobar resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report findings on the use of ENB\u2010guided dye marking among participants in the NAVIGATE study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>NAVIGATE is a prospective, multicentre, global and observational cohort study of ENB use in patients with lung lesions. The current subgroup report is a prespecified 1\u2010month interim analysis of ENB\u2010guided pleural dye marking in the NAVIGATE United States cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The full United States cohort includes 1215 subjects from 29 sites (April 2015 to August 2016). Among those, 23 subjects (24 lesions) from seven sites underwent dye marking in preparation for surgical resection. ENB was conducted for dye marking alone in nine subjects while 14 underwent dye marking concurrent with lung lesion biopsy, lymph node biopsy and\/or fiducial marker placement. The median nodule size was 10\u00a0mm (range 4\u201022) and 83.3% were &lt;20\u00a0mm in diameter. Most lesions (95.5%) were located in the peripheral third of the lung, at a median of 3.0\u00a0mm from the pleura. The median ENB\u2010specific procedure time was 11.5\u00a0minutes (range 4\u201038). The median time from dye marking to resection was 0.5 hours (range 0.3\u201024). Dye marking was adequate for surgical resection in 91.3%. Surgical biopsies were malignant in 75% (18\/24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, ENB\u2010guided dye marking to localize lung lesions for surgery was safe, accurate and versatile. More information is needed about surgical practice patterns and the utility of localization procedures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13077","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T12:58:09Z","timestamp":1566219489000},"page":"700-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Pleural dye marking of lung nodules by electromagnetic navigation bronchoscopy"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3490-5647","authenticated-orcid":false,"given":"Mark R.","family":"Bowling","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Brody School of Medicine East Carolina University Greenville North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik E.","family":"Folch","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep J.","family":"Khandhar","sequence":"additional","affiliation":[{"name":"Inova Health System, Virginia Cancer Specialists Fairfax Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Arenberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Awais","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center, Mercy Health Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Minnich","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Pritchett","sequence":"additional","affiliation":[{"name":"Pinehurst Medical Clinic and FirstHealth Moore Regional Hospital Pinehurst North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otis B.","family":"Rickman","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sztejman","sequence":"additional","affiliation":[{"name":"Virtua Medical Group Marlton New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos J.","family":"Anciano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Brody School of Medicine East Carolina University Greenville North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209120"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.04.026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.08.026"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.07.078"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.2.r99ma35561"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.09.112"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.08.016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.5.1559"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.163.2.7518642"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2252011025"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CPM.0000000000000232"},{"key":"e_1_2_11_14_1","article-title":"Electromagnetic navigation bronchoscopy triple contrast dye marking for lung nodule localization","author":"Ng CSH","year":"2019","journal-title":"Thorac Cardiovasc Surg"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753466619841234"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0228-y"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0403-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.11.013"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.05.026"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aorn.2013.09.016"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-1502-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/imi.0000000000000387"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/imi.0000000000000440"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.130"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.115"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx313"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.10.105"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8030379"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.04.085"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486205"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.12.044"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.03.010"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.13077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.13077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:48:56Z","timestamp":1694242136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/crj.13077"],"URL":"https:\/\/doi.org\/10.1111\/crj.13077","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,2]]},"assertion":[{"value":"2019-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}