{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:01:00Z","timestamp":1780362060917,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA)\u2014overlap syndrome\u2014have a substantially greater risk of morbidity and mortality, compared to those with either COPD or OSA alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this retrospective study was to identify clinical modifiable factors associated with COPD exacerbations and all\u2010cause mortality in patients with overlap syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The electronic records of patients with simultaneous COPD and OSA who had a documented acute exacerbation of COPD during a 42\u2010month period were evaluated for reviewed. A control group of overlap syndrome patients without exacerbations was matched 1:1 for age and body mass index. Vital status and cause of death were assessed through the population death registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 225 eligible cases, 92 patients had at least one episode of COPD exacerbation. There was no significant association between severity of airflow limitation and apnoea hypopnea index (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.31). After adjusting for confounding variables, patients who had at least one COPD exacerbation were more likely to be active smokers (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), have poorer lung function (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and less likely to adhere to continuous positive airway pressure (CPAP) use (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). All\u2010cause mortality was also correlated with low forced expiratory volume in 1 second (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006), CPAP use (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.007), and burden of comorbidities (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lung function and CPAP use were independent predictors of COPD exacerbations and all\u2010cause mortality in a cohort of patients with overlap syndrome. These factors should be taken into account when considering the management and prognosis of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13079","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T08:24:31Z","timestamp":1566462271000},"page":"643-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Predictive factors for COPD exacerbations and mortality in patients with overlap syndrome"],"prefix":"10.1111","volume":"13","author":[{"given":"Philippe","family":"Jaoude","sequence":"first","affiliation":[{"name":"The Veterans Affairs Western New York Healthcare System Buffalo New York"},{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Jacob School of Medicine University at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-8776","authenticated-orcid":false,"given":"Ali A.","family":"El\u2010Solh","sequence":"additional","affiliation":[{"name":"The Veterans Affairs Western New York Healthcare System Buffalo New York"},{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Jacob School of Medicine University at Buffalo Buffalo New York"},{"name":"Department of Epidemiology and Environmental Health, School of Public Health and Health Professions University at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)00402-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.02.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-009-0266-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.1.7812577"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"32","article-title":"Sleep apnoea syndrome in Nepal","volume":"7","author":"Chokhani R","year":"2005","journal-title":"Nepal Med Coll J"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1869OC"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7574"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.03.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.01213.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.2.459"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-120039210"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.040527"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335467"},{"key":"e_1_2_9_15_1","unstructured":"(GOLD) GIfCOLD;PagesRevised 2019.https:\/\/goldcopd.org\/gold-reports\/. 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