{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:59:07Z","timestamp":1775509147778,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Peripheral pulmonary lesions (PPL) are difficult to diagnose. We analysed the diagnostic values and risks of endobronchial ultrasonography with a guide sheath (EBUS\u2010GS) and computed tomography\u2010guided transthoracic needle aspiration (CT\u2010TTNA) in diagnosing PPL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected 250 cases received EBUS\u2010GS examination, and 279 cases received CT\u2010TTNA examination. We analysed the diagnosis results and the complications of each operation and determined the relevant indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biopsy was successful in 239 cases (95.6%) using EBUS\u2010GS and in 279 cases (100%) using CT\u2010TTNA. Lesions were smaller than or equal to 30\u00a0mm for biopsy using EBUS\u2010GS in 60.7% of the cases. The distances of lesions from the chest wall were greater than 80 mm for EBUS\u2010GS examination in 89.1% of the cases. The diagnostic rate of EBUS\u2010GS was 78.2%, including 41.8% (100 cases) malignant diseases. EBUS\u2010GS is a highly safe method. The distances of lesions from the chest wall were no greater than 80\u00a0mm for CT\u2010TTNA examination in 90.0% of the cases. The diagnosis rate using CT\u2010TTNA was 94.6%, including 90.0% (251 cases) malignant diseases. For CT\u2010TTNA, there is a high chance of complications such as pneumothorax and intrapulmonary hemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EBUS\u2010GS and CT\u2010TTNA each have their own limitations. EBUS\u2010GS has a slightly lower diagnostic rate but higher safety, while CT\u2010TTNA has a higher diagnostic rate but requires attention to complications. For lesions 80\u00a0mm more from the chest wall, we recommend EBUS\u2010GS. For lesions 80\u00a0mm from or closer to the chest wall, we recommend CT\u2010TTNA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13088","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T12:49:11Z","timestamp":1567687751000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnosis of peripheral pulmonary lesions using endobronchial ultrasonography with a guide sheath and computed tomography guided transthoracic needle aspiration"],"prefix":"10.1111","volume":"13","author":[{"given":"Jun","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Oncology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7567-7073","authenticated-orcid":false,"given":"Ye","family":"Gu","sequence":"additional","affiliation":[{"name":"Department 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