{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:31:53Z","timestamp":1780043513231,"version":"3.53.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["16CR3036A"],"award-info":[{"award-number":["16CR3036A"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670006"],"award-info":[{"award-number":["81670006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The characteristics of Allergic Bronchopulmonary Aspergillosis (ABPA) based on its radiological classification is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the clinical significances of ABPA patients with central bronchiectasis (ABPA\u2010CB) by different radiological classifications of mucus plugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ABPA\u2010CB patients from a pulmonary hospital between 2008 and 2015 were retrospectively included and analysed. According to the chest imaging in their first visit to physician, the ABPA\u2010CB patients were divided into two groups based on the presence of high\u2010attenuation mucus (HAM) or low\u2010attenuation mucus (LAM). The primary endpoint was ABPA relapse within 1 year since the glucocorticoid withdrawal. The relationship between the imaging findings and the clinical prognosis was illuminated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 125 ABPA patients were analysed in this study. Compared to the LAM group, the HAM group presented higher blood eosinophil cells counts, higher rates of <jats:italic>Aspergillus<\/jats:italic> detection isolated in sputum and expectoration of brownish\u2010black mucus plugs, more affected lobes and segments, poorer pulmonary function and higher rate of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical characteristics and prognosis of ABPA\u2010CB patients are closely related to its radiological phenotype of mucus plugs in the central bronchiectasis. Clinicians should promote a diversity of personalized treatments for different patients with different radiological characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13111","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T18:14:55Z","timestamp":1574532895000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The clinical characteristics and prognosis of ABPA are closely related to the mucus plugs in central bronchiectasis"],"prefix":"10.1111","volume":"14","author":[{"given":"Hai\u2010Wen","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care 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Respiratory and Critical Care Medicine Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Bin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu\u2010Wu","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 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