{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:11:23Z","timestamp":1774105883059,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purposes<\/jats:title><jats:p><jats:italic>Escherichia coli <\/jats:italic>is one of the most common pathogens in nosocomial and community\u2010acquired infections, but is an uncommon respiratory pathogen. However, this pathogen may at times be seen in respiratory secretions. The study aims to determine the clinical and prognostic value of <jats:italic>E. coli<\/jats:italic> in respiratory secretions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cultures of respiratory secretions from hospitalized and outpatients between 2009 and 2016 were screened for isolation of <jats:italic>E. coli<\/jats:italic>. We defined three groups of patients: \u201cSensitive (S)\u201d\u2014growth of <jats:italic>E. coli<\/jats:italic> sensitive to all antimicrobials tested; Intermediate (I)\u2014resistant to 1\u20102 antimicrobial classes; and \u201cResistant (R)\u201d\u2014resistant to at least three antibiotic classes. We compared factors associated with resistant strains and outcomes between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty patients with <jats:italic>E. coli<\/jats:italic> isolates from respiratory secretions were identified while screening 177\u00a0712 (4.5: 10\u00a0000 samples). Of the <jats:italic>E. Coli<\/jats:italic>\u2010positive cultures, 11 were from ambulatory patients, 31 patients were hospitalized and 37 were hospitalized and intubated. Ten people had bronchiectasis and 29 had COPD. Patients with resistant <jats:italic>E. coli<\/jats:italic> had significantly more hospitalization days prior to positive culture (S\u00a0=\u00a01.2\u00a0\u00b1\u00a01.89 days, I\u00a0=\u00a01.23\u00a0\u00b1\u00a01.5\u00a0days and <jats:italic>R<\/jats:italic>\u00a0=\u00a03.7\u00a0\u00b1\u00a05.4\u00a0days, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). Mortality was higher in patients with a resistant strain (R) versus (I) or (S) (76.7%, 31.8% and 26.7%, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and remained significantly elevated after correction for prior hospital days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pulmonary infection due to <jats:italic>E. coli<\/jats:italic> is uncommon. Isolation of resistant <jats:italic>E. coli<\/jats:italic> is associated with length of previous hospitalization, elevated mortality and may be viewed as a nosocomial pathogen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13116","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T11:26:48Z","timestamp":1575458808000},"page":"205-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical characteristics and outcomes of patients with <i>Escherichia coli<\/i> in airway samples"],"prefix":"10.1111","volume":"14","author":[{"given":"Sonia","family":"Schneer","sequence":"first","affiliation":[{"name":"Pulmonary Division Lady Davis\u2010Carmel Medical Center Haifa Israel"},{"name":"The B. Rappaport Faculty of Medicine Technion, Israel Institute of Technology Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-1542","authenticated-orcid":false,"given":"Johad","family":"Khoury","sequence":"additional","affiliation":[{"name":"Pulmonary Division Lady Davis\u2010Carmel Medical Center Haifa Israel"},{"name":"The B. Rappaport Faculty of Medicine Technion, Israel Institute of Technology Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yochai","family":"Adir","sequence":"additional","affiliation":[{"name":"Pulmonary Division Lady Davis\u2010Carmel Medical Center Haifa Israel"},{"name":"The B. Rappaport Faculty of Medicine Technion, Israel Institute of Technology Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nili","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Epidemiology Carmel Medical Center Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pninit","family":"Shaked Mishan","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory Carmel Medical Center Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifra","family":"Ken\u2010Dror","sequence":"additional","affiliation":[{"name":"Clinical Microbiological Laboratory, Central Laboratories Haifa &amp; Western Galilee Clalit Health Services Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Weber","sequence":"additional","affiliation":[{"name":"The B. Rappaport Faculty of Medicine Technion, Israel Institute of Technology Haifa Israel"},{"name":"Clinical Microbiological Laboratory, Central Laboratories Haifa &amp; Western Galilee Clalit Health Services Haifa Israel"},{"name":"Infectious Disease and Infection Control Unit Carmel Medical Center Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Meler","sequence":"additional","affiliation":[{"name":"Pulmonary Division Lady Davis\u2010Carmel Medical Center Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysha","family":"Khateeb","sequence":"additional","affiliation":[{"name":"The B. Rappaport Faculty of Medicine Technion, Israel Institute of Technology Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-3398","authenticated-orcid":false,"given":"Michal","family":"Shteinberg","sequence":"additional","affiliation":[{"name":"Pulmonary Division Lady Davis\u2010Carmel Medical Center Haifa Israel"},{"name":"The B. Rappaport Faculty of Medicine Technion, Israel Institute of Technology Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/514583"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.174"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/604713"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-07"},{"key":"e_1_2_8_7_1","volume-title":"The Europian Cystic Fibrosis Society annual data report (Year 2014) Version 02.2016","author":"Zolin A"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.02.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.7.2766-2767.2000"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"e_1_2_8_11_1","volume-title":"Methods for Antimicrobial Susceptibility Testening of Anaerobic Bacteria","author":"Carpenter DE"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13115"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2017.06.025"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.13116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.13116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T20:27:27Z","timestamp":1694032047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,16]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/crj.13116"],"URL":"https:\/\/doi.org\/10.1111\/crj.13116","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,16]]},"assertion":[{"value":"2019-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}