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The natural course of COPD is aggravated by episodes of respiratory symptom worsening termed exacerbations that contribute to disease progression. Acute Exacerbations of COPD (AECOPD) can be triggered by a multitude of different factors, including respiratory tract infections, various exposures, prior exacerbations, non\u2010adherence to treatment and associated comorbidities. AECOPD are associated with an inexorable decline of lung function and\u00a0a significantly worse survival outcome. This review will summarise the most important aspects regarding the impact of different factors that contribute to COPD exacerbations.<\/jats:p>","DOI":"10.1111\/crj.13129","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T07:31:00Z","timestamp":1575876660000},"page":"183-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Risk factors of chronic obstructive pulmonary disease exacerbations"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-7479","authenticated-orcid":false,"given":"Stanca\u2010Patricia","family":"Hogea","sequence":"first","affiliation":[{"name":"Department of Pulmonology University of Medicine and Pharmacy \u201cVictor Babe\u0219\u201d Timi\u0219oara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Tudorache","sequence":"additional","affiliation":[{"name":"Department of 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