{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:05:34Z","timestamp":1784721934295,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To examine the correlation of pulmonary functions and neutrophyle\/lymphocyte ratio (NLR) with optic coherence tomography findings in stable chronic obstructive pulmonary disease (COPD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five COPD (110 eyes) and 48 control cases (96 eyes) were enrolled. COPD patients were grouped as Group 1 (mild\u2010moderate) and Group 2 (severe) according to GOLD classification. Subfoveal choroidal thickness (SFCT), ganglion cell\u2010inner plexiform layer (GCIP) and retinal nerve fiber layer (RNFL) analysis by SD\u2010OCT were performed in follow up. NLR was calculated by blood cell count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inferior RNFL and average GCIP of COPD were lower than control during the initial and sixth month examination (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, respectively). Average RNFL and SFCT were lower in COPD patients in sixth month examination (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.020, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015, respectively). Average, temporal, inferior, nasal RNFL and SFCT in sixth month examination were significantly lower in severe COPD (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 for all), but average GCIP were similar (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015). Disease duration, Modified Medical Research Council (mMRC) and attacks\/year showed significant negative correlations, whereas forced expiratory volume in 1 second (FEV1) and FEV1\/forced vital capacity (FVC) showed significant positive correlations with OCT values. NLR was significantly higher in COPD cases compared to control (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and had a negative correlation with GCIP values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic obstructive pulmonary disease severity is shown to have a negative effect on OCT measurements. SD\u2010OCT can reflect severity of inflammation, and suggested to be used in follow up of COPD cases. NLR may have a role to predict the ganglion cell damage in COPD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13140","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T06:03:15Z","timestamp":1577512995000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Correlat\u0131on of neutrophyle\/lymphocyte ratio and pulmonary parameters with optic coherence tomography findings in stable chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-6501","authenticated-orcid":false,"given":"Pinar Altiaylik","family":"Ozer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Ufuk University Faculty of Medicine Ankara 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