{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:53:08Z","timestamp":1762005188552,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, we assessed the clinical effect of inhaled verapamil on hospitalized COPD patients in a randomized and double\u2010blind study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>COPD patients randomly received 10\u00a0mg of inhaled verapamil or 4 cc nebulized distilled water (DW) as placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients enrolled in each group with no difference in baseline characteristics. Mean age was 64.95\u00a0\u00b1\u00a08.9 and 66.9\u00a0\u00b1\u00a010.74\u00a0years in verapamil and control group; respectively, (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><jats:p>The mean dyspnea score was 6.4\u00a0\u00b1\u00a01.2 and 6.2\u00a0\u00b1\u00a01.8 in the verapamil and control group, respectively and decreased to 4.9\u00a0\u00b1\u00a01.3 and 5.7\u00a0\u00b1\u00a01.8 after the intervention. The mean change in the verapamil group was significantly higher, (22.43%\u00a0\u00b1\u00a010.6% vs 8.7%\u00a0\u00b1\u00a012.1%), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00.<\/jats:p><jats:p>Unlike the control group, the FEV1 value in the verapamil group significantly increased and reached to 1.17\u00a0\u00b1\u00a00.4\u00a0L from 1.03\u00a0\u00b1\u00a00.4. There was a significant decrease in airway resistance in both groups after intervention. However, neither total lung capacity and residual volume nor forced vital capacity changed significantly. Moreover, oxygen saturation in the verapamil group changed 4.8%\u00a0\u00b1\u00a02.5% and this improvement in the control group was 1.8\u00a0\u00b1\u00a01 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00). Smoker subjects, ones with PAP more than 35\u00a0mm\u00a0Hg and obese patients benefit from verapamil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The beneficial impact of inhaled verapamil on the diminishing of dyspnea score along with its bronchodilatory effect would make this selective calcium blocker agent a therapeutic option in COPD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13142","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T06:34:38Z","timestamp":1578119678000},"page":"370-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic effects of nebulized verapamil on chronic obstructive pulmonary disease: A randomized and double\u2010blind clinical trial"],"prefix":"10.1111","volume":"14","author":[{"given":"Rama","family":"Bozorgmehr","sequence":"first","affiliation":[{"name":"Clinical Research Development Unit Shohadaye Tajrish Hospital Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-5409","authenticated-orcid":false,"given":"Maryam","family":"Edalatifard","sequence":"additional","affiliation":[{"name":"Thoracic Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enayat","family":"Safavi","sequence":"additional","affiliation":[{"name":"Thoracic Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Besharat","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Thoracic Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Ghorbani","sequence":"additional","affiliation":[{"name":"Tracheal Diseases Research Center National Research Institute of Tuberculosis and Lung Disease Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamidreza","family":"Abtahi","sequence":"additional","affiliation":[{"name":"Thoracic Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahideh","family":"Amini","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Clinical Pharmacy Department Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guitti","family":"Pourdowlat","sequence":"additional","affiliation":[{"name":"Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Disease (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"20","article-title":"COPD: obstructed lungs","volume":"22","author":"Casey G","year":"2016","journal-title":"Nurs N Z"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1016\/j.amjmed.2007.04.007"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1001\/jama.294.10.1255"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1513\/pats.200708-124ET"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"199","article-title":"Hypoxemia in patients with COPD: cause, effects, and disease progression","volume":"6","author":"Kent BD","year":"2011","journal-title":"Int J COPD"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1164\/ajrccm.149.2.8306040"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1183\/09031936.97.10061285"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1378\/chest.125.1.249"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.2165\/00003495-198224050-00004"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1016\/j.amjmed.2017.12.018"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1016\/0091-6749(83)90065-9"},{"key":"e_1_2_9_13_1","first-page":"27","article-title":"Is there a new indication and route of administration for an old drug in pulmonary hypertension (ph) secondary to COPD? 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