{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:01:29Z","timestamp":1785200489871,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Why do only some of patients who are prescribed angiotensin converting enzyme inhibitors (ACE\u2010I) develop cough? The pathogenesis of ACE\u2010I\u2010induced cough remains controversial and requires further studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aim to investigate whether asthma is a contributing cause of ACE\u2010I\u2010induced cough.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients attending a cardiology clinic between March 2016 and March 2017 who were diagnosed with ACE\u2010I induced cough were included in this study. ACE\u2010I\u2010induced cough was defined as cough which developed within 4 weeks after initiation of ACE\u2010I therapy and which improved within 4 weeks after discontinuation of the ACE\u2010I. Patients who had received ACE\u2010I treatment for at least 6 months without side effects were included in the study as a control group. Face\u2010to\u2010face questionnaires, pulmonary function tests (PFT) and skin prick tests were applied to all the patients. If there was discordance between asthma history and PFT results, a methacholine bronchial provocation test (BPT) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 43 patients with ACE\u2010I induce cough were compared with 50 controls. Bronchial hyperreactivity (BHR), rhinitis, atopy and family history of asthma were more frequent in patients with ACE\u2010I induced cough (<jats:italic>P<\/jats:italic> &lt; .001). Patients with ACE\u2010I\u2010induced cough had significantly higher incidence of diagnosed asthma [OR\u00a0=\u00a08.28 (95%CI: 3.26\u201021.03) <jats:italic>P<\/jats:italic> &lt; .001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Asthma and an atopic background constitute a substantial risk factor for ACE\u2010I induced cough. The presence of underlying asthma should be investigated in patients diagnosed with ACE inhibitor induced cough. However, the fact that most asthma patients tolerate ACE\u2010I therapy, indicates that other cofactors are likely involved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13143","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T13:35:02Z","timestamp":1578144902000},"page":"382-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The presence of underlying asthma should be investigated in patients diagnosed with ACE inhibitor induced cough"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-6291","authenticated-orcid":false,"given":"\u0130nsu","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of Chest Diseases, Division of Immunology and Allergy Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-2661","authenticated-orcid":false,"given":"Murat","family":"T\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Division of Immunology and Allergy Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Baran Ketencio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-3433","authenticated-orcid":false,"given":"Zeki","family":"\u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-4896","authenticated-orcid":false,"given":"Nuri","family":"Tutar","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Sema","family":"Oymak","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130nci","family":"G\u00fclmez","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Newton Franklin","family":"Adkinson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Clinical Immunology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2003.00484.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-3-234"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1994.tb01989.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440090103010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.3.640"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.4.991"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91547-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1_suppl.169S"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2006.05746.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-814"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.3.544"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.4.922"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.1.127"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200355200"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.2.8049818"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.11.1851"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.27212"},{"key":"e_1_2_9_19_1","unstructured":"Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease Diagnosis of Diseases of Chronic Airflow Limitation: Asthma COPD and Asthma-COPD Overlap Syndrome (ACOS) 2017. 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