{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:49:35Z","timestamp":1781765375342,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ultrasound elastography, is a pioneer sonographic modality that is conducted during endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) in order to increase the accuracy of sampling location. The current study aims to evaluate the usefulness of elastography during EBUS\u2010TBNA in a population with a high prevalence of anthracosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective single\u2010blinded study was performed on 69 lymph nodes (LNs) of patients with\u00a0mediastinal lymphadenopathy\u00a0undergoing EBUS\u2010TBNA and\u00a0EBUS\u2010elastography\u00a0from October 2017 to July 2018. The stiffness level of the tissue was translated into a color to demonstrate the hardness of tissue. Blue and total areas of each section were measured to calculate the hardness of each LN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine LNs were evaluated by elastography. Twenty percent of LNs were malignant. There was a statistical difference between malignant and non\u2010malignant nodes based on color dominancy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.032). However, with the exclusion of anthracosis nodes from the analysis, the difference was more significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Moreover, when the blue dominancy was used as the predictor of malignancy or anthracosis, the results showed a significant correlation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The usefulness of elastography in selecting the hardest area of tissue that is appropriate for diagnosing diseases has been proven previously. Since in countries with a high prevalence of anthracosis, blue color achieved using elastography predicts either malignancy or anthracosis so, cases with blue dominancy of LNs in elastography and the white color in the EBUS\u2010TBNA indicate anthracosis\u2010caused calcification should be reconsidered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13159","type":"journal-article","created":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T14:44:06Z","timestamp":1581173046000},"page":"488-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The utility of elastography during EBUS\u2010TBNA in a population with a high prevalence of anthracosis"],"prefix":"10.1111","volume":"14","author":[{"given":"Atefeh","family":"Abedini","sequence":"first","affiliation":[{"name":"Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Razavi","sequence":"additional","affiliation":[{"name":"Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Farahani","sequence":"additional","affiliation":[{"name":"Department of Interventional Pulmonology Tracheal Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Emami","sequence":"additional","affiliation":[{"name":"Tobacco Prevention and Control Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forouzan","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Pathology National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9765-3611","authenticated-orcid":false,"given":"Arda","family":"Kiani","sequence":"additional","affiliation":[{"name":"Tracheal Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(19)30085-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340511798038684"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/016173469101300201"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.04.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.187866"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"190","article-title":"Anthracosis of the lung: evaluation of potential causes","volume":"30","author":"Mirsadraee M","year":"2015","journal-title":"Iranian J Med Sci"},{"issue":"11","key":"e_1_2_9_8_1","first-page":"3129","article-title":"Multi\u2010gene expression in anthracosis of the lungs as one of the risk factors for non\u2010small cell lung cancer","volume":"18","author":"Jamaati H","year":"2017","journal-title":"Asian Pac J Cancer Prevention"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"175","article-title":"What do we know about anthracofibrosis? 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