{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:18:50Z","timestamp":1784146730351,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU\u2010PUB\/31346\/2017"],"award-info":[{"award-number":["PTDC\/SAU\u2010PUB\/31346\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tuberculin skin test (TST) has been the standard test for screening for <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection for decades. Identifying persons with latent tuberculosis infection (LTBI) is crucial, as they constitute a reservoir that sustains the global tuberculosis (TB) epidemic. However, different factors, such as HIV infection, can lower the sensitivity of the test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to determine the TST sensitivity in active TB patients and to ascertain risk factors that could be associated with false\u2010negative results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of all active TB notifications with a TST result (n\u00a0=\u00a08833), from 2008 to 2015. TST results were interpreted using a 5\u00a0mm and 10\u00a0mm cutoff. Bivariate and multivariate logistic regression analysis were used to evaluate the association of sociodemographic and clinical factors with false\u2010negative TST results and to develop predictive risk models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TST presented an overall sensitivity of 63.8% (5\u00a0mm) and 56.1% (10\u00a0mm). HIV infection was the risk factor with the strongest association with false\u2010negative results (aOR 4.65\u20105\u00a0mm; aOR 5.05\u201010\u00a0mm). Other factors such as chronic renal failure (CRF) (aOR 1.55\u20105\u00a0mm; aOR 1.73\u201010\u00a0mm), alcohol abuse (aOR 1.52\u20105\u00a0mm; aOR 1.31\u201010\u00a0mm), drug abuse (aOR 1.90\u20105\u00a0mm; aOR 1.76\u201010\u00a0mm) or age \u226565\u00a0years (OR 1.69\u20105\u00a0mm and 10\u00a0mm) were also associated with a probability of false\u2010negative results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results highlight the importance of knowing which factors influence TST results, such as HIV status, substance abuse or age, thus improving its usefulness as a screening method for LTBI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13166","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T04:10:30Z","timestamp":1581567030000},"page":"541-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Tuberculin skin test and predictive host 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