{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:40:57Z","timestamp":1790278857311,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Microalbuminuria (MA) is considered a reflection of systemic capillary leak and an early marker of acute stress reaction to the surgical insult, proportional to the severity of the initiating condition and predictive of the individual response to surgical stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We conducted a prospective study to assess for the variation of MA within 4 days after thoracic surgery. We correlated observed MA levels with both their respective PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> respiratory ratio and the onset of postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010centre study enrolled 255 consecutive patients having an American Society of Anaesthesiologists (ASA)\u00a0score\u00a0\u2264\u00a03. The mean age was 62 years with 67% male. All patients were scheduled for elective pulmonary resection. MA was measured in urine samples as the albumin\u2010to\u2010creatinine ratio (A\/C), prior to, at and after extubation up to 96 hours. PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> was measured at extubation and on the first postoperative day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, preoperative A\/C levels resulted normal, with a significant average increase at extubation which peaked 6 hours later (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Larger postoperative A\/C increases were observed in patients who developed postoperative complications, compared to those without these complications (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.019). Moreover, patients undergoing major open pulmonary resections had larger postoperative A\/C increases, compared to those undergoing minor video\u2010assisted thoracic surgery\u00a0resections (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.006). At the time of extubation, A\/C was inversely related to the PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.25; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.038). Peak A\/C &gt; 61\u00a0mg\/g (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0003) was associated with postoperative cardio\u2010pulmonary complications (OR 3.85; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within 6 hours after extubation, MA assessment may be a rapid and relatively inexpensive method for better predicting perioperative risk in an ASA score \u2264\u00a03 population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13169","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T04:45:15Z","timestamp":1581655515000},"page":"564-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microalbuminuria assessment after thoracic surgery: Early identification of complication risks"],"prefix":"10.1111","volume":"14","author":[{"given":"Lucio","family":"Cagini","sequence":"first","affiliation":[{"name":"Department of Medicine S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"},{"name":"Thoracic Surgery Unit, Department of Surgical Science S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-7374","authenticated-orcid":false,"given":"Marco","family":"Andolfi","sequence":"additional","affiliation":[{"name":"Department of Medicine S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"},{"name":"Thoracic Surgery Unit AOU Ospedali Riuniti di Ancona Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Potenza","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Surgical Science S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Surgical Science S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Vannucci","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Surgical Science S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Berti","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Surgical Science S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"Reboldi","sequence":"additional","affiliation":[{"name":"Department of Medicine S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Puma","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Surgical Science S. Maria della Misericordia Hospital, University of Perugia Medical School Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"S69","article-title":"Clinical practice recommendations 2001: diabetic nephropathy","volume":"24","author":"American Diabetes Association","year":"2001","journal-title":"Diabetes Care"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.538132"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.09.043"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.11.1132"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.338"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059931"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199910000-00004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(00)00149-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.123083"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-9514(09)70081-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470023589"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146.ch8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00388.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00246.2009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000228914.73550.BD"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.20.4.306"},{"issue":"2","key":"e_1_2_8_19_1","first-page":"e71","article-title":"Fluid and electrolyte balance after major thoracic surgery by bioimpedance and endocrine evaluation","volume":"40","author":"Cagini L","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu348"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5772\/54667"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.12.009"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.13169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.13169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:05:14Z","timestamp":1694001914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,25]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/crj.13169"],"URL":"https:\/\/doi.org\/10.1111\/crj.13169","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,25]]},"assertion":[{"value":"2019-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}