{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:29:27Z","timestamp":1783816167750,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The differentiation of benign and malignant sub\u2010centimetre (\u226410\u00a0mm) lung nodules (SCLNs) is challenging. Computed tomography (CT)\u2010guided biopsy has been widely used for the diagnosis of lung nodules or masses. However, studies regarding CT\u2010guided biopsies for SCLNs are still lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the feasibility and diagnostic accuracy of CT\u2010guided biopsies for SCLNs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From December 2011 to October 2017, 102 patients with SCLNs underwent CT\u2010guided lung biopsies. Data on technical success, diagnostic performance and procedure\u2010related complications were collected and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The technical success rate of CT\u2010guided biopsy for SCLNs was 99% (101\/102). One patient failed to undergo the procedure. A total of 101 SCLNs in 101 patients were examined. The biopsy diagnostic results included 38 malignant cases, 1 suspected malignant case, 5 specific benign cases and 57 non\u2010specific benign cases. The final diagnoses included 49 malignant cases, 49 benign cases and 3 cases of undiagnosed lesions. The sensitivity, specificity and overall diagnostic accuracy were 80% (39\/49), 100% (49\/49) and 90% (88\/98), respectively. Based on the univariate and multivariate logistic regression analyses, the independent risk factors for diagnostic failure were small tissue sample numbers (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.048) and procedure\u2010related hemoptysis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). Pneumothorax was found in 13 patients (13%). Based on the univariate and multivariate logistic regression analyses, the independent risk factor for pneumothorax was the decubitus position (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011). Hemoptysis was found in seven patients (7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CT\u2010guided biopsy is a safe and highly accurate diagnostic method for SCLNs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13172","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T14:51:59Z","timestamp":1582210319000},"page":"605-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Computed tomography\u2010guided biopsy for sub\u2010centimetre lung nodules: Technical success and diagnostic accuracy"],"prefix":"10.1111","volume":"14","author":[{"given":"Yu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology Xuzhou Central Hospital Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Xuzhou Central Hospital Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-6557","authenticated-orcid":false,"given":"Yu\u2010Fei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology Xuzhou Central Hospital Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-313X","authenticated-orcid":false,"given":"Yi\u2010Bing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology Xuzhou Central Hospital Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9525-9741","authenticated-orcid":false,"given":"Jing\u2010Ya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Xuzhou Central Hospital Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.01.020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2391050343"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2019.07.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-4131-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.02.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2644-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2019.0189"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018181482"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-008-0325-y"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.12.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-019-0240-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008703"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.02.58"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_1017_17"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.6.1801665"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2253011465"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.10156"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000071087.76348.C7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4766-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2018.03.017"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.13172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.13172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T04:17:28Z","timestamp":1693973848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/crj.13172"],"URL":"https:\/\/doi.org\/10.1111\/crj.13172","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]},"assertion":[{"value":"2019-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}