{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:52:08Z","timestamp":1766087528414,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870042","81700045","81900050"],"award-info":[{"award-number":["81870042","81700045","81900050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["16ZR1429000"],"award-info":[{"award-number":["16ZR1429000"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute vasoreactivity testing (AVT) which reflects the compliance of the pulmonary vascular bed has been proven to be of prognostic value. The purpose of the present study is to explore the sex differences of hemodynamics during the AVT and their impact on event\u2010free survival in patients with chronic thromboembolic pulmonary hypertension (CTEPH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010six patients underwent a right heart catheterization and AVT at Shanghai Pulmonary Hospital from February 2009 to February 2018. Univariate and multiple stepwise regression analysis were performed to determine the predictors of independent event\u2010free survival, and receiver operating characteristic curve was plotted to determine the cut\u2010off value of independent parameters in CTEPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in both demographics and hemodynamics between male and female patients with CTEPH. Except \u0394PVR\/PVR showed a significantly higher difference in female than male patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.034). Male patients had higher mRAP of pre\u2010 and post\u2010AVT than female patients in the event\u2010free subgroup, while, female patients showed higher PVR of pre\u2010AVT than male patients in the event subgroup (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The mRAP and SvO<jats:sub>2<\/jats:sub> were independent predictors of event\u2010free survival in female patients both before and after the AVT, whereas \u0394SvO<jats:sub>2<\/jats:sub> was an independent predictor of event\u2010free survival in male patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hemodynamics during the AVT varied between male and female patients with CTEPH. Both sexes displayed unique hemodynamic responses that were independently able to predict event\u2010free survival. Therefore, better estimates of prognosis in CTEPH can be made when sex differences are also taken into consideration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13173","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T09:12:18Z","timestamp":1582535538000},"page":"611-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sex differences of hemodynamics during acute vasoreactivity testing to predict the outcomes of chronic thromboembolic pulmonary hypertension"],"prefix":"10.1111","volume":"14","author":[{"given":"Yi\u2010Lan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation School of Medicine Shanghai Pulmonary Hospital Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Zhe","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Respiratory 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