{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:07:40Z","timestamp":1790489260781,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Home noninvasive mechanical ventilation (HNIV) in patients with chronic hypercapnic respiratory failure (CHRF) may improve the health\u2010related quality of life (HRQoL) and reduce hospitalizations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effects of HNIV on HRQoL, sleep quality and hospitalization rates in restrictive thoracic diseases (RTD) and chronic obstructive pulmonary disease (COPD) patients with CHRF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, single center study patients divided into two groups; the COPD and the RTD groups. HRQoL assessed by The Medical Outcome Study 36\u2010Item Short\u2010form Health Survey (SF\u201036) and Severe Respiratory Insufficiency (SRI); the sleep quality was assessed by Epworth and Pittsburgh Sleep Quality Index questionnaires. The patients were reevaluated first month, third months, sixth months and 1 year following HNIV establishment, during which time, hospitalization rates were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety (COPD n\u00a0=\u00a050, RTD n\u00a0=\u00a040) out of 102 eligible patients completed the study. Significant improvements in blood gases and HRQoL were observed in the first month of HNIV establishment and remained stable. Mean\u00a0\u00b1\u00a0SD SRI summary scale improved significantly from 30\u00a0\u00b1\u00a012 baseline to 65\u00a0\u00b1\u00a016 at 1\u00a0year in COPD group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and from 39\u00a0\u00b1\u00a013 to 63\u00a0\u00b1\u00a018 in RTD group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). HNIV reduced hospitalization rates from a mean of 1.9\u00a0\u00b1\u00a01.1 to 0.5\u00a0\u00b1\u00a00.9 in COPD group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and a mean of 1.9\u00a0\u00b1\u00a01 to 0.5\u00a0\u00b1\u00a00.7 in RTD group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HNIV improves HRQoL, sleep quality and gas exchange and reduces hospitalizations in patients with CHRF regardless of etiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13221","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T21:37:13Z","timestamp":1590615433000},"page":"880-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effects of home noninvasive ventilation on the quality of life and physiological parameters of patients with chronic respiratory 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