{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:09:42Z","timestamp":1761419382122,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pulmonary Hypertension (PH) is a frequent comorbidity in Obesity Hypoventilation Syndrome (OHS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated long\u2010term outcome of OHS with a particular emphasis on PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective design, 64 patients with OHS and established noninvasive positive pressure ventilation (NPPV), were assessed by serum biomarkers, right heart catheterization, blood gases analysis, lung function, Epworth\u2010Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), World Health Organization\u2010functional class (WHO\u2010FC) and health\u2010related quality of life (HRQL) via the Severe Respiratory Insufficiency (SRI) questionnaire. After a planned follow\u2010up of 5\u00a0years patients were reassessed regarding vital status, WHO\u2010FC, ESS, SRI, PSQI, body mass index (BMI) and NPPV use. Prognostic markers were explored using univariate and multivariate Cox regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 5\u2010year follow\u2010up, BMI tended to decrease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05), while WHO\u2010FC, ESS and PSQI remained unchanged. HRQL deteriorated in terms of SRI summary score and most subdomains (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 each). NPPV adherence still was high (89%), while daily NPPV use increased from 6.7 (5.1; 8.0)\u00a0h\/d to 8.2 (7.4; 9.0)\u00a0h\/d (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). After a 5\u2010year follow\u2010up, mortality was 25.8%. In univariate regression analyses only age\u00a0&gt;\u00a069.5\u00a0years (HR\u00a0=\u00a04.145, 95%\u2010CI\u00a0=\u00a01.180\u201014.565, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016), NT\u2010proBNP\u00a0&gt;\u00a01256\u00a0pg\/mL (HR\u00a0=\u00a05.162, 95%\u2010CI\u00a0=\u00a01.136\u201023.467, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), diffusion capacity for carbon monoxide (DLCO, %pred) (HR\u00a0=\u00a00.341, 95%\u2010CI\u00a0=\u00a00.114\u20101.019, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) and higher oxygen use during daytime (HR\u00a0=\u00a05.236, 95%\u2010CI\u00a0=\u00a01.489\u201018.406, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) predicted mortality. No independent factor predicting mortality was detected in multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite a high long\u2010term NPPV use HRQL worsened. Age, oxygen use at baseline, DLCO (%pred) and NT\u2010proBNP, as a surrogate parameter for PH, were related to long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13225","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T14:52:27Z","timestamp":1591541547000},"page":"940-947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term outcome with focus on pulmonary hypertension in Obesity Hypoventilation Syndrome"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-8410","authenticated-orcid":false,"given":"Stephan","family":"Budweiser","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III Division of Pulmonary and Respiratory Medicine RoMed Clinical Centre Rosenheim 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