{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:36:49Z","timestamp":1789439809609,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\u2010Aim<\/jats:title><jats:p>Noninvasive mechanical ventilation (NIV) failure rate is reported to be 5%\u201060% of intensive care unit (ICU) patients. Despite all precautions and well\u2010known reasons, the risk factors of NIV failure are unclear for chronic obstructive pulmonary disease (COPD) with acute respiratory failure (ARF). The aim of this study was to examine risk factors for NIV failure in COPD patients with ARF, other than well defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The retrospective cohort study was done in ICU of a chest disease hospital. All consecutive COPD patients with hypercapnic ARF were enrolled in study. Demographics, comorbidities, arterial blood gases, reasons of ARF and length of ICU stay were recorded. NIV success was defined as discharge from ICU and NIV failure was defined as need for intubation or died during NIV. Patients were grouped into; NIV failure and success. The groups were compared and NIV failure risk factors were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 265 NIV success and 142 NIV failure patients were enrolled into the study. Logistic regression test showed the risk factors for NIV failure; higher APACHE\u2010II (\u2265 29) (OR:11.71, CI95%4.39\u201031.18,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), culture positivity (OR:7.59, CI95%3.21\u201017.92,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), sepsis (OR:6.53 CI95%3.59\u201011.85,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and pneumonia (OR:3.71 CI95%0.60\u20102.02,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.043) significantly. COPD patients using home\u2010based NIV had less risk for NIV failure (OR: 0.49 CI95%0.28\u20100.87,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>APACHE II\u00a0\u2265\u00a029 score, culture positivity, sepsis and pneumonia are the risk factors for NIV failure in COPD patients with ARF. COPD patients previously on home\u2010based NIV showed half times less risk for NIV failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13245","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T23:43:26Z","timestamp":1596757406000},"page":"1083-1089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors of unfavorable outcomes in chronic obstructive pulmonary disease patients treated with noninvasive ventilation for acute hypercapnic respiratory failure"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-125X","authenticated-orcid":false,"given":"Sinem","family":"Gungor","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-6118","authenticated-orcid":false,"given":"Ozlem Yazicioglu","family":"Mocin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-1943","authenticated-orcid":false,"given":"Eylem","family":"Tuncay","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-8332","authenticated-orcid":false,"given":"Emine","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-5905","authenticated-orcid":false,"given":"Nezihe Ciftaslan","family":"Goksenoglu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-8638","authenticated-orcid":false,"given":"Birsen","family":"Ocakli","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital Istanbul 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-0016","authenticated-orcid":false,"given":"Zuhal","family":"Karakurt","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Health Sciences University Sureyyapasa Pulmonary Disease and Pulmonary Surgery Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02426-2016"},{"key":"e_1_2_10_3_1","first-page":"CD004104","article-title":"Non\u2010invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease","volume":"7","author":"Osadnik CR","year":"2017","journal-title":"Cochrane Database Syst 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