{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:14:25Z","timestamp":1784229265411,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The effectiveness of non\u2010invasive mechanical ventilation (NIV) in the management of COPD patients suffering from acute respiratory failure (ARF) as a consequence of exacerbation of the disease, is well established. However, data on long\u2010term outcomes and their predictors, including the individual response to NIV, are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate predictors for short\u2010 and long\u2010term mortality in this study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was performed including all patients admitted to the Medium Respiratory Care Unit of Maastricht University Medical Center in Maastricht, the Netherlands, with hospitalized exacerbation of COPD (H\u2010ECOPD) with ARF requiring NIV for the first time between January 2009 and December 2011. An extensive number of potential predictors of outcomes, including the response to NIV, were determined on admission and during hospitalization. Univariate and multivariate logistic regression was used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight consecutive patients with moderate to severe COPD (mean age 71.0 \u00b1 10.7 years; 48.7% males) were included; In\u2010hospital, 1\u2010year and 2\u2010year mortality rates were 14.1%, 43.6% and 56.4%, respectively. Independent risk factors for 2\u2010year mortality were: advanced age (odds ratio(OR) 1.025; confidence interval (CI) 1.002\u20101.049;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.037), prolonged NIV use more than 8 days (OR:1.054;CI:1.006\u20101.104;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.027) and no successful response to NIV (OR:2.392;CI:1.297\u20104.413;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with an H\u2010ECOPD requiring NIV for the first time, constitute a severely ill patient group with high in\u2010hospital and 2\u2010year mortality. This study identified advanced age, NIV use more than 8 days and unsuccessful response to NIV as clinical important independent predictors for long\u2010term mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13251","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T03:40:54Z","timestamp":1597203654000},"page":"1144-1152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Predictors for long\u2010term mortality in COPD patients requiring non\u2010invasive positive pressure ventilation for the treatment of acute respiratory failure"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2844-3500","authenticated-orcid":false,"given":"Roy T. M.","family":"Sprooten","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Center Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot G. U.","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Medical Clinic 1 University Hospital Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlou T. H. F.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolle A. M.","family":"Cobben","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiel F. M.","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Center Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"},{"name":"CIRO Horn The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits M. E.","family":"Franssen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University Medical Center Maastricht The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Maastricht The Netherlands"},{"name":"CIRO Horn The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152618"},{"issue":"3","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1164\/rccm.201605-1014OC","article-title":"Acute exacerbations and lung function loss in smokers with and without chronic obstructive pulmonary disease","volume":"195","author":"Dransfield MT","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.040527"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342036"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.4.8887592"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.2.459"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13538"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158727"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00791-2016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-1094OC"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S42632"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.5430"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09030422"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00085304"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2016.01.021"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01795.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201709-1852OC"},{"key":"e_1_2_9_20_1","unstructured":"Global Strategy for the diagnosis managment and prevention of chronic obstructive lung disease 2019 Report.www.goldcopd.com."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-208209"},{"issue":"10","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.20452\/pamw.2460","article-title":"Noninvasive ventilation for hypercapnic exacerbation of chronic obstructive pulmonary disease: factors related to noninvasive ventilation failure","volume":"124","author":"Nicolini A","year":"2014","journal-title":"Pol Arch Med Wewn"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.9.708"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139702"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-016-1516-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.04.005"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0892-9"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010487"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90696-E"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00214-2017"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201011-1887OC"},{"issue":"1","key":"e_1_2_9_32_1","first-page":"9","article-title":"Effectiveness and predictors of failure of noninvasive mechanical ventilation in acute respiratory failure","volume":"40","author":"Martin\u2010Gonzalez F","year":"2016","journal-title":"Med Intensiva"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.7.550"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02323-0"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40248-018-0149-0"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01720714"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-19"},{"issue":"24","key":"e_1_2_9_38_1","first-page":"424","article-title":"Clinical practice guideline: non\u2010invasive mechanical ventilation as treatment of acute respiratory failure","volume":"105","author":"Schonhofer B","year":"2008","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/976783"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00094203"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02637-2017"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.13251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T17:48:54Z","timestamp":1723398534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/crj.13251"],"URL":"https:\/\/doi.org\/10.1111\/crj.13251","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]},"assertion":[{"value":"2019-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}