{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:11:04Z","timestamp":1778947864900,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Viral respiratory tract infections are the leading cause of acute wheezing in children with a significant risk of hospital admission, risk of recurrence and subsequent asthma. Human respiratory syncytial virus (RSV) and human rhinovirus (RV) in childhood wheezing are widely studied; however, accessible PCR assays enabled diagnosis of other pathogens, including bocavirus (hBOV) and metapneumovirus (hMPV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to evaluate the prevalence of respiratory viruses in children hospitalized for acute wheezing along with demographic and clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 101 children, <jats:italic>n<\/jats:italic> = 50 (49.5%) with wheezy bronchitis, <jats:italic>n<\/jats:italic> = 34 (33.7%) with acute bronchiolitis and <jats:italic>n<\/jats:italic> = 17 (16.8%) with exacerbation of asthma; (median age 1.41\u00a0\u00b1\u00a02.84 years). Multiplex real\u2010time PCR assay was used for virus detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One or more viruses were detected in 83.2% subjects: RSV in 44.6%, followed by RV (23.8%), hBOV and hMPV (both 11.9%); other viruses were less frequent (&lt;8%). Viral coinfection was found in 38 (37.6%) of children. ANCOVA analysis revealed significantly higher total IgE concentrations in the hMPV\u2010positive subgroup compared to RSV (34 kU\/L vs 12.7 kU\/L; <jats:italic>P<\/jats:italic> = .009) and RV (13.3 kU\/L, <jats:italic>P<\/jats:italic> = .022). For both hMPV and hBOV an association with atopic dermatitis (AD) was observed: aOR for hMPV and AD was 5.6 (95%CI: 1.4\u201022.7; <jats:italic>P<\/jats:italic> = .016) and 4.7 for hBOV and AD (95%CI: 1.3\u201018; <jats:italic>P<\/jats:italic> = .024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Viral detection ratio in wheezy respiratory tract infections in Polish children is high (83.2%), with both hBOV and hMPV at 11.9% The results also suggest possible relationship of hBOV wheezy infection with nonspecific markers of atopy in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13261","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T21:51:23Z","timestamp":1597355483000},"page":"1201-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Human bocavirus and metapneumovirus in acute wheezing in children\u2014Is there a link with atopy?"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-8946","authenticated-orcid":false,"given":"Paulina","family":"Sobkowiak","sequence":"first","affiliation":[{"name":"Department of Pneumonology, Allergology and Clinical Immunology Pozna\u0144 University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Miko\u015b","sequence":"additional","affiliation":[{"name":"Department of Pneumonology, Allergology and Clinical Immunology Pozna\u0144 University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Br\u0119borowicz","sequence":"additional","affiliation":[{"name":"Department of Pneumonology, Allergology and Clinical Immunology Pozna\u0144 University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Szczepankiewicz","sequence":"additional","affiliation":[{"name":"Department of Pneumonology, Allergology and Clinical Immunology Pozna\u0144 University of Medical Sciences Poznan Poland"},{"name":"Laboratory of Molecular and Cell Biology Department of Pneumonology, Allergology and Clinical Immunology Pozna\u0144 University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e318216b41f"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/512196"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.121582"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12318"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.031"},{"issue":"4","key":"e_1_2_10_7_1","first-page":"729","article-title":"Czynniki wirusowe ostrych zaka\u017ce\u0144 dr\u00f3g oddechowych u ma\u0142ych dzieci. 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