{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:55:54Z","timestamp":1747184154623,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010small\u2010cell lung cancers (NSCLCs) are only eligible to undergo curative surgical resection in &lt;20% of patients. In patients with inoperable NSCLC, computed tomography (CT)\u2010guided radioactive seed insertion (RSI) is a common treatment practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the relative efficacy of chemotherapy alone versus chemotherapy in combination with CT\u2010guided RSI in patients with advanced NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the Pubmed, Embase, and Cochrane Library databases for relevant articles published as of July 2020. Complete and total response rates (CR and TR, respectively) served as the primary endpoints for this meta\u2010analysis, with disease control (DC) rate, myelosuppression rate, progression\u2010free survival (PFS), overall survival (OS), and CT\u2010guided RSI\u2010related pneumothorax serving as secondary endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, eight studies incorporating 281 patients that underwent combination treatment and 297 patients that underwent chemotherapy along were included in this meta\u2010analysis. The CR (21.5% vs. 4.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001), TR (73.8% vs. 42.6%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001), and DC (94.1% vs. 78.2%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001) rates were significantly higher for patients in the combined treatment group relative to patients in the chemotherapy only group. Furthermore, pooled PFS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001) and OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006) were significantly longer for patients in the combined treatment group, whereas no differences in pooled myelosuppression rates were observed between groups (34.3% vs. 30.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.47). The pooled rate of CT\u2010guided RSI\u2010related pneumothorax was 15%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combination chemotherapy and CT\u2010guided RSI can significantly improve clinical response and prolong survival in advanced\u2010stage NSCLC patients without inducing other significant toxic side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13283","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T11:27:49Z","timestamp":1601206069000},"page":"187-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radioactive seeds insertion with chemotherapy for advanced non\u2010small\u2010cell lung cancer: A meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"Hong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Oncology Binzhou Medical University Hospital  Binzhou China  <!--Query ID=\"q3\" Text=\"AUTHOR: Please check and confirm whether the affiliations and corresponding details have been set correctly.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Binzhou Medical University Hospital  Binzhou China  <!--Query ID=\"q3\" Text=\"AUTHOR: Please check and confirm whether the affiliations and corresponding details have been set correctly.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-341X","authenticated-orcid":false,"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology Binzhou Medical University Hospital  Binzhou China  <!--Query ID=\"q3\" Text=\"AUTHOR: Please check and confirm whether the affiliations and corresponding details have been set correctly.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-643X","authenticated-orcid":false,"given":"Zhi\u2010Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology Binzhou Medical University Hospital  Binzhou China  <!--Query ID=\"q3\" Text=\"AUTHOR: Please check and confirm whether the affiliations and corresponding details have been set 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