{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:56:04Z","timestamp":1747184164106,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2018YFC1311900"],"award-info":[{"award-number":["2018YFC1311900"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The American Thoracic Society (ATS) guideline for methacholine challenge testing (MCT) recommended using the English Wright (EW) nebuliser. However, other brands of nebulisers are also indicated to be acceptable for this technique, but further validation of nebuliser performance is recommended.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the methacholine provocation concentration causing a 20% fall in forced expiratory volume in 1 second (PC<jats:sub>20<\/jats:sub>\u2010FEV<jats:sub>1<\/jats:sub>) measured by using EW nebuliser and DV 646 nebuliser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were randomly assigned to undergo 2\u2010min tidal breathing methacholine challenge with either EW or DV 646 nebuliser on two separate days, which were at least 24 hours but not more than 7 days apart. The above procedure was repeated for each subject in 1 month, but the nebulisers were selected in a reverse order.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study includes 15 mild and stable asthmatic patients. The geometric means (SD) of methacholine PC<jats:sub>20<\/jats:sub> measured with using EW and DV 646 nebulisers were 1.82 (6.38) mg\/mL versus 0.83 (1.82) mg\/mL, respectively in the initial two visits and 2.56 (6.29) mg\/mL versus 0.78 (1.40) mg\/mL in the following two visits (both <jats:italic>P<\/jats:italic> &lt; 0.05). There are well correlations between PC20\u2010EW1 and PC20\u2010EW2 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.99, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), PC20\u2010DV1 and PC20\u2010DV2 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.88, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and between PC20\u2010EW1 and PC20\u2010DV1 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.91, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01), PC20\u2010EW2 and PC20\u2010DV2 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.78, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PC<jats:sub>20<\/jats:sub>\u2010FEV<jats:sub>1<\/jats:sub> measured by using the two conventional jet nebulisers was both repeatable and the results were highly correlated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13374","type":"journal-article","created":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T10:41:25Z","timestamp":1618137685000},"page":"863-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two\u2010minute tidal breathing methacholine bronchial challenge: Comparison of two jet nebulisers"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6949-3785","authenticated-orcid":false,"given":"Zheng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, State Key Lab of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Lab of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Firestone Institute for Respiratory Health, The Research Institute of St. Joe\u2019s Hamilton, St. Joseph\u2019s Healthcare, Department of Medicine McMaster University  Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqing","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Lab of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"An","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Lab of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University  Guangzhou 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