{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:35Z","timestamp":1787014055840,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF2020R1F1A1076452"],"award-info":[{"award-number":["NRF2020R1F1A1076452"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Associations between anemia and allergic diseases have been reported, but the relationship of iron deficiency with airway dysfunction in children remains unclear. We aimed to investigate the relationship between abnormal iron parameters and lung function in schoolchildren.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Four hundred and forty\u2010five children (10\u201312\u00a0years\u2010old) from 11 elementary schools in were enrolled. The relationships of different iron parameters (hemoglobin, serum iron, transferrin saturation, and serum ferritin) with lung function evaluated by impulse oscillometry (airways resistance\u00a0at 5\u00a0Hz [Rrs5], 10\u00a0Hz [Rrs10], and the difference of Rrs5 and Rrs20 Hz [Rrs5\u201020]), and with exhaled nitric oxide (FeNO) were evaluated after adjustment for confounders including height, sex, and body mass index\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score, and for additional covariates that could affect airway function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Total airway dysfunction represented by Rrs5 was reduced in participants with low serum iron level (a\u03b2: \u22120.13, 95% CI: \u22120.23 to \u22120.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.040) after adjustment for key confounders, but did not correlate with other iron profiles. Reduced oscillometric lung function recorded as Rrs5\u201020 was related with low serum iron and high serum ferritin, but the results were inconsistent after multiple comparisons. Associations were not observed with serum hemoglobin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Decreased serum iron level was related with airway dysfunction represented as oscillomteric Rrs5. Our results suggest a relationship of reduced lung function with abnormal iron status in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.13375","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T22:25:44Z","timestamp":1618352744000},"page":"870-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Abnormal iron status is independently associated with reduced oscillometric lung function in schoolchildren"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-5729","authenticated-orcid":false,"given":"Eun Kyo","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hallym University Kangnam Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-0753","authenticated-orcid":false,"given":"Ju Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Kandong Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0145-7067","authenticated-orcid":false,"given":"Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chonnam National University Hospital Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-286X","authenticated-orcid":false,"given":"Myongsoon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Soon Chun Hyang University Gumi Hospital Soon Chun Hyang University College of Medicine  Gumi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-065X","authenticated-orcid":false,"given":"Hye Mi","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHA Bundang Medical Center CHA University School of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0297-9446","authenticated-orcid":false,"given":"Hey Sung","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Kandong Sacred Heart Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-5511","authenticated-orcid":false,"given":"Youn Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics CHA Gangnam Medical Center CHA University School of Medicine  Seoul Republic of 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