{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:01:44Z","timestamp":1790920904995,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) is an emerging, rapidly evolving pandemic, hypertension is one of the most common co\u2010existing chronic conditions and a risk factor for mortality. Nearly one\u2010third of the adult population is hypertensive worldwide, it is urgent to identify the factors that determine the clinical course and outcomes of COVID\u201019 patients with hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>148 COVID\u201019 patients with pre\u2010existing hypertension with clarified outcomes (discharge or deceased) from a national cohort in China were included in this study, of whom 103 were discharged and 45 died in hospital. Multivariate regression showed higher odds of in\u2010hospital death associated with high\u2010sensitivity cardiac troponin (hs\u2010cTn) &gt; 28\u00a0pg\/ml (hazard ratio [HR]: 3.27, 95% confidence interval [CI]: 1.55\u20136.91) and interleukin\u20106 (IL\u20106) &gt; 7\u00a0pg\/ml (HR: 3.63, 95% CI:1.54\u20138.55) at admission. Patients with uncontrolled blood pressure (BP) (n\u00a0=\u00a052) which were defined as systolic BP \u2265140\u00a0mm\u00a0Hg or diastolic BP \u226590\u00a0mm\u00a0Hg for more than once (\u22652 times) during hospitalization, were more likely to have ICU admission (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.037), invasive mechanical ventilation (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028), and renal injury (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). A stricter BP control with the threshold of 130\/80\u00a0mm\u00a0Hg was associated with lower mortality. Treatment with renin\u2010angiotensin\u2010aldosterone system (RAAS) suppressors, including angiotensin\u2010converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARB), and spironolactone, was associated with a lower rate of ICU admission compared to other types of anti\u2010hypertensive medications (8 (22.9%) vs. 25 (43.1%), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among COVID\u201019 patients with pre\u2010existing hypertension, elevated hs\u2010cTn and IL\u20106 could help clinicians to identify patients with fatal outcomes at an early stage, blood pressure control is associated with better clinical outcomes, and RAAS suppressors do not increase mortality and may decrease the need for ICU admission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13382","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T02:05:47Z","timestamp":1620093947000},"page":"915-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictors of fatal outcomes among hospitalized COVID\u201019 patients with pre\u2010existing hypertension in China"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9372-1648","authenticated-orcid":false,"given":"Tao","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Diseases Guangzhou Institute of Respiratory Health the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Vascular Diseases Guangzhou Medical University  Guangzhou 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