{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:27:48Z","timestamp":1787610468876,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Average volume\u2010assured pressure support (AVAPS), a dual mode, delivers a set tidal volume (TV) per kg by adjusting the pressure between upper and lower inspiratory positive airway pressures (IPAP). Thus, ventilation is presumed to be happened effectively by sending a guaranteed TV. This study was aimed to evaluate the effectiveness of AVAPS mode in critically ill patients with acute hypercarbic respiratory failure (HRF) and compare the results with bilevel positive airway pressure\u2010spontaneous\/timed (BPAP\u2010S\/T) mode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty patients were assigned to BPAP\u2010S\/T (n\u00a0=\u00a029) and AVAPS modes (n\u00a0=\u00a031). Maximum IPAP was started at 20 cmH<jats:sub>2<\/jats:sub>O and minimum IPAP was set at 5 cmH<jats:sub>2<\/jats:sub>O higher than expiratory positive airway pressure (EPAP) in AVAPS mode. IPAP was started at 15 cmH<jats:sub>2<\/jats:sub>O in BPAP\u2010S\/T mode. IPAP levels were titrated up to 30 cmH<jats:sub>2<\/jats:sub>O during noninvasive mechanic ventilation (NIMV) with a targeted TV of 6\u20138 mL\/kg. Patients were followed for 5 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences were found in pH, paCO<jats:sub>2<\/jats:sub>, HCO<jats:sub>3<\/jats:sub>, TV and EPAP between the two groups when compared separately by days. Maximum IPAP levels were significantly high in AVAPS mode in all times (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The length of stay (LOS) in intensive care unit (ICU) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.994) and hospital (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.509), hours of NIMV use per day (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.101) and NIMV success rate (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.931) were identical between the two groups. ICU (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.931), hospital (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.800), 6\u2010month (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.919) and 1\u2010year (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.645) mortality rates were also not different between the both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AVAPS mode had similar efficiency with BPAP\u2010S\/T mode regarding the NIMV treatment success in critically ill patients with acute HRF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13401","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T07:55:33Z","timestamp":1621497333000},"page":"973-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of critically ill patients with acute hypercarbic respiratory failure by average volume\u2010assured pressure support mode"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2150-6866","authenticated-orcid":false,"given":"T\u00fcrkay","family":"Akba\u015f","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, Division of Intensive Care D\u00fczce University  D\u00fczce Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9596-6913","authenticated-orcid":false,"given":"G\u00fcl\u015fah","family":"Altun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine D\u00fczce University  D\u00fczce Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02426-2016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.2005125"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.4.1225"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.815"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-009-9167-1"},{"issue":"7","key":"e_1_2_10_7_1","first-page":"1139","article-title":"Respiratory pattern and tidal volume differ from pressure support and volume\u2010assured pressure support in amyotrophic lateral sclerosis","volume":"14","author":"Nicholson TT","year":"2017","journal-title":"Ann Am Thorac 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