{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:01:58Z","timestamp":1780362118220,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although long\u2010term home non\u2010invasive ventilation (H\u2010NIV) has been used among chronic hypercapnic COPD patients, its clinical benefit is still on debate. We aim to assess the impact of H\u2010NIV in chronic hypercapnic COPD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>COPD patients who initiated H\u2010NIV between January 2010 and December 2017 were included. Patients with concomitant respiratory disorders were excluded. Acute exacerbation (AE) before and 2\u00a0years after H\u2010NIV initiation was assessed as main outcome. Secondary outcomes included lung function and gas exchange parameters. Survival since H\u2010NIV initiation was determined, and factors related with survival were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010two patients were enrolled. A decrease in partial pressure of carbon dioxide (PaCO<jats:sub>2<\/jats:sub>) in arterial blood (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and an improvement of partial pressure of oxygen (PaO<jats:sub>2<\/jats:sub>) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were achieved using a high\u2010intensity H\u2010NIV. Regarding lung function, residual volume (RV) reduced (<jats:italic>p<\/jats:italic>\u2009=\u20090.010) and forced\u2010expiratory volume in 1\u00a0s (FEV<jats:sub>1<\/jats:sub>) improved (<jats:italic>p<\/jats:italic>\u2009=\u20090.043) after H\u2010NIV initiation. No significant differences in 6\u2010min walking test (6MWT) were found. Compared with the year before H\u2010NIV initiation, the number of AE diminished in the first and in the second years of follow\u2010up (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The median survival was 79.0\u00a0months (95% confidence interval [CI], 52.9\u2013105.1), and the covered distance in 6MWT predicted survival (hazard ratio [HR]\u2009=\u20090.026, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) in the multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010intensity H\u2010NIV significantly improved FEV1 and hyperinflation, decreased frequency of AEs and led to a remarkable median survival, which was independently predicted by the walking distance in 6MWT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13419","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T18:20:41Z","timestamp":1625509241000},"page":"1130-1138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term home non\u2010invasive ventilation in chronic hypercapnic chronic obstructive pulmonary disease patients: Real\u2010world impact on lung function, acute exacerbations and survival"],"prefix":"10.1111","volume":"15","author":[{"given":"Cl\u00e1udia","family":"Freitas","sequence":"first","affiliation":[{"name":"Pulmonology Department Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Serino","sequence":"additional","affiliation":[{"name":"Pulmonology Department Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Pulmonology Department Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Pinto","sequence":"additional","affiliation":[{"name":"Sleep and Non\u2010invasive Ventilation Unit Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafalda","family":"Van Zeller","sequence":"additional","affiliation":[{"name":"Sleep and Non\u2010invasive Ventilation Unit Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Faculty of Medicine University of Porto  Porto Portugal"},{"name":"i3S \u2013 Institute for Research and Innovation in Health\/Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Pulmonology Department Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Sleep and Non\u2010invasive Ventilation Unit Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Faculty of Medicine University of Porto  Porto Portugal"},{"name":"i3S \u2013 Institute for Research and Innovation in Health\/Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto  Porto Portugal"},{"name":"Intensive Care Medicine Department Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Drummond","sequence":"additional","affiliation":[{"name":"Sleep and Non\u2010invasive Ventilation Unit Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"},{"name":"Faculty of Medicine University of Porto  Porto Portugal"},{"name":"i3S \u2013 Institute for Research and Innovation in Health\/Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease.GOLD report 2020. 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