{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:56:07Z","timestamp":1747184167260,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with chronic obstructive pulmonary disease (COPD) commonly have comorbidities which may impact both symptoms and prognosis. Endoscopic lung volume reduction (ELVR) with endobronchial valves (EBV) is an innovative, effective and safe treatment for patients with severe emphysema who remain symptomatic despite optimal medical therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate medical comorbidities associated with increased risk of complications after EBV procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a retrospective cohort review of patients with severe, heterogeneous emphysema who underwent Zephyr\u00ae EBV installation for ELVR. Demographics, baseline comorbidities, dyspnea scores, data regarding procedure, pulmonary function test, minimal clinically important difference and post\u2010EBV complications were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total 82 participants, 24 were identified as having a post procedure complication. There was a significant difference in the incidence of type 2 diabetes mellitus (T2DM) at baseline (25%) in complication group compared with non\u2010complication group (5.1%) (<jats:italic>p<\/jats:italic> value\u00a0<jats:italic>=\u20090.01<\/jats:italic>). There was also a significant difference between baseline coronary artery disease (CAD) in those with (58.3%) or without (29.3%) complication (<jats:italic>p\u2009=\u20090.01<\/jats:italic>). Multivariate analysis of other covariables, identified associations of both CAD and T2DM with a heightened risk of complication (adjusted OR 4.19 CI: 1.23\u201314.2, <jats:italic>p<\/jats:italic> value\u00a0<jats:italic>=\u20090.02<\/jats:italic> and adjusted OR of 6.1 CI: 1.3\u201326.1, <jats:italic>p<\/jats:italic> value\u00a0<jats:italic>=\u20090.02<\/jats:italic> respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study found that patients with severe, heterogeneous emphysema who undergo ELVR utilizing Zephyr\u00ae EBV and suffer complications during post\u2010procedure period are more likely to have CAD or T2DM as baseline comorbidity. These data suggest that baseline CAD and T2DM might be predictive of increased risk of complications following ELVR with EBV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13426","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T03:39:20Z","timestamp":1627097960000},"page":"1194-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of complications rise with coronary artery disease and diabetes mellitus after endobronchial valve placement in severe heterogeneous emphysema"],"prefix":"10.1111","volume":"15","author":[{"given":"Sebastian","family":"Fernandez\u2010Bussy","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-2131","authenticated-orcid":false,"given":"Anna","family":"Kornafeld","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-3420","authenticated-orcid":false,"given":"Gonzalo","family":"Labarca","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy University of Concepcion  Concepcion Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Abia\u2010Trujillo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janani S.","family":"Reisenauer","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix J.","family":"Herth","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Care Medicine Thoraxklinik at the University of Heidelberg  Heidelberg Germany"},{"name":"Translational Lung Research Center Heidelberg (TLRCH)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease.GOLD Report\u20142020 Global strategy for prevention diagnosis and management of COPD2020. Available from:https:\/\/goldcopd.org\/gold-reports\/"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201803-0590OC"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492274"},{"key":"e_1_2_11_5_1","first-page":"1","article-title":"The REACH trial: a randomized controlled trial assessing the safety and effectiveness of the spiration(R) valve system in the treatment of severe emphysema","author":"Li S","year":"2018","journal-title":"Respiration"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504183"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00128008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114307"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00012408"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.05.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12642"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00133805"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2099"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201707-1327OC"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201607-1383OC"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201902-0383OC"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60001-0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00161611"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507807"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900928"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.09.006"},{"key":"e_1_2_11_22_1","first-page":"1","article-title":"Bronchoscopic lung volume reduction with endobronchial zephyr valves for severe emphysema: a systematic review and meta\u2010analysis","author":"Labarca G","year":"2019","journal-title":"Respiration"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-19-367"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-37280"},{"issue":"2","key":"e_1_2_11_25_1","first-page":"S160","article-title":"Complications after tracheal resection and reconstruction: prevention and treatment","volume":"8","author":"Auchincloss HG","year":"2016","journal-title":"J Thorac Dis"},{"key":"e_1_2_11_26_1","article-title":"Impact of diabetes mellitus on survival and hospitalization after lung transplantation","volume":"48","author":"Riou M","year":"2016","journal-title":"Eur Respir J"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.09.013"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-016-1355-z"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.5603\/ARM.2017.0011"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002323"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0700-8"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14470"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.13426","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:47:11Z","timestamp":1693216031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/crj.13426"],"URL":"https:\/\/doi.org\/10.1111\/crj.13426","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"type":"print","value":"1752-6981"},{"type":"electronic","value":"1752-699X"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"2021-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}