{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:55:11Z","timestamp":1786985711716,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endobronchial ultrasound transbronchial needle aspiration (EBUS\u2010TBNA) is a safe and minimally invasive procedure for evaluating hilar and mediastinal lymph nodes. The reported sensitivity and specificity of EBUS\u2010TBNA are 95% and 97%, respectively. A comparison of diagnostic sensitivity for lymph nodes suspected of lung cancer according to needle size in EBUS\u2010TBNA is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the diagnostic sensitivity of the 19\u2010G, 21\u2010G, 22\u2010G and 25\u2010G needles for lymph nodes suspected of non\u2010small cell lung cancer (NSCLC) using EBUS\u2010TBNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search from PubMed, EMBASE, LILACS, DOAJ and CENTRAL through October 2020 was performed by two reviewers. The extracted data were evaluated using STATA\u00ae and Open Meta Analyst software for meta\u2010analysis with a binary method model to compare sensitivity, specificity and summary receiver operating characteristic curve for each needle size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen studies including 1296 participants were considered for the analysis. The overall sensitivity of EBUS\u2010TBNA was 88.2% (95% CI 84%, 91%) and 93% (95% CI 88%, 95%) for the 19\u2010G needle, 87.6% (95% CI 79.6%, 92.8%) for the 21\u2010G needle and 85% (95% CI 80%, 88%) for the 22\u2010G needle. The overall sensitivity of EBUS\u2010TBNA for diagnosing NSCLC was 88.3% (95% CI, 81%, 93%) and 92.9% (95% CI, 85%, 97%) for the 19\u2010G needle, 89.4% (95% CI 79.4%, 94.8%) for the 21\u2010G needle and 82.1% (95% CI 66%, 91%) for the 22\u2010G needle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 19\u2010G, 21\u2010G and 22\u2010G needles present a similarly high diagnostic sensitivity in EBUS\u2010TBNA. The 19\u2010G needle provided better sample adequacy for molecular and immunohistochemical testing, improving diagnostic yield in this subgroup.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13436","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T02:36:11Z","timestamp":1629167771000},"page":"1328-1336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Comparing diagnostic sensitivity of different needle sizes for lymph nodes suspected of lung cancer in endobronchial ultrasound transbronchial needle aspiration: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"Alejandra","family":"Yu Lee\u2010Mateus","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Garcia\u2010Saucedo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Abia\u2010Trujillo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-3420","authenticated-orcid":false,"given":"Gonzalo","family":"Labarca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine University of Concepcion  Concepcion Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge M.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Fernandez\u2010Bussy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32832b8a45"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2015.672"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201801-045OC"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2007CI"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.03.016"},{"key":"e_1_2_10_9_1","unstructured":"StataCorp.Stata statistical software: release 14. 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