{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:20:19Z","timestamp":1761157219348},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>When a severe asthma exacerbation occurs in an obese pediatric patient, it is unknown if this body type persists in future encounters. Persistent obesity can lead to future asthma exacerbations. The main study objective is to evaluate the persistence of a BMI percentile \u226585th in children 5\u00a0years after the first reported diagnosis of status asthmaticus. We hypothesized that a hospital admission for status asthmaticus was associated with persistence of a BMI percentile \u226585th.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a long\u2010term retrospective observational cohort study utilizing TriNetX \u00ae electronic health record (EHR) data. We included subjects aged 2 to 18\u2009years of age with a diagnosis of status asthmaticus. Study population was divided into two groups based on their admission body mass index percentile: (underweight\/healthy weight [&lt;85th percentile] and overweight\/obese [\u226585th percentile]) and evaluated for the following outcomes: age, race, ethnicity, diagnostic codes, and BMI percentiles (initially and 5\u00a0years after diagnosis of status asthmaticus).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 129 subjects (<jats:italic>n<\/jats:italic>%) (76 [58.9%] underweight\/healthy weight and 53 [41.1%] overweight\/obese) were included. Children that were initially overweight\/obese with status asthmaticus had significantly increased odds of continuing to be overweight\/obese 5\u00a0years after diagnosis compared to children who were underweight\/healthy weight at baseline (OR\u2009=\u20097.50 [95% confidence interval, 3.20\u201317.60; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overweight\/obese asthmatic children are at risk of continuing to be obese several years after being diagnosed with status asthmaticus. This study reinforces the notion that when an asthmatic obese child presents with status asthmaticus, a thorough evaluation of nutrition, physical activity, and asthma control should be considered to reduce the risk of persistent obesity and possibly future asthma exacerbations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13444","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T10:44:05Z","timestamp":1630147445000},"page":"1368-1374","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Frequency of persistent obesity 5\u00a0years after first time diagnosis of status asthmaticus"],"prefix":"10.1111","volume":"15","author":[{"given":"Conrad","family":"Krawiec","sequence":"first","affiliation":[{"name":"Pediatric Critical Care Medicine, Department of Pediatrics Penn State Hershey Children's Hospital  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Fang","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duane","family":"Williams","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Medicine, Department of Pediatrics Penn State Hershey Children's Hospital  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Medicine, Department of Pediatrics Penn State Hershey Children's Hospital  Hershey Pennsylvania USA"},{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2012.12.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106028"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2017-0094"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/17.5.251"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120023499"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2019.100886"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2017-0265"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018\u20102119"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwz257"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30462-4"},{"key":"e_1_2_11_13_1","unstructured":"Centers for Disease Control and Prevention (CDC).Children's BMI tool for schools. 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