{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:59:42Z","timestamp":1792522782097,"version":"4.5.0"},"reference-count":157,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease characterized by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and architecture is destroyed, compliance is lost, and gas exchange is compromised in this debilitating condition that leads inexorably to respiratory failure and death within 3\u20135\u2009years of diagnosis. This review discusses treatment approaches to IPF in current use and those that appear promising for future development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Source<\/jats:title>\n                    <jats:p>The data were obtained from the Randomized Controlled Trials and scientific studies published in English literature. We used search terms related to IPF, antifibrotic treatment, lung transplant, and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Etiopathogenesis of IPF is not fully understood, and treatment options are limited. Pathological features of IPF include extracellular matrix remodeling, fibroblast activation and proliferation, immune dysregulation, cell senescence, and presence of aberrant basaloid cells. The mainstay therapies are the oral antifibrotic drugs pirfenidone and nintedanib, which can improve quality of life, attenuate symptoms, and slow disease progression. Unilateral or bilateral lung transplantation is the only treatment for IPF shown to increase life expectancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clearly, there is an unmet need for accelerated research into IPF mechanisms so that progress can be made in therapeutics toward the goals of increasing life expectancy, alleviating symptoms, and improving well\u2010being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.13466","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T03:54:38Z","timestamp":1641786878000},"page":"84-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":307,"title":["Idiopathic pulmonary fibrosis: Current and future treatment"],"prefix":"10.1111","volume":"16","author":[{"given":"Daniel S.","family":"Glass","sequence":"first","affiliation":[{"name":"Department of Medicine and Biomedical Research Institute NYU Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grossfeld","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biomedical Research Institute NYU Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Renna","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biomedical Research Institute NYU Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Agarwala","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biomedical Research Institute NYU Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Spiegler","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biomedical Research Institute NYU Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"DeLeon","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biomedical Research Institute NYU Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-2441","authenticated-orcid":false,"given":"Allison B.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biomedical Research Institute NYU Long Island School of Medicine  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60052-4"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200701-044OC"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70101-8"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028019862497"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30866-8"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.1.9001319"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110551"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.1067609"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00005"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0288-SA"},{"key":"e_1_2_14_13_1","first-page":"245","article-title":"Optimizing quality of life in patients with idiopathic pulmonary fibrosis","volume":"11","author":"Manen MJ","year":"2017","journal-title":"Ther Adv Respir Dis"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197660"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13665-019-00238-7"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00041411"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13943"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2020.10.008"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00479-2020"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-034428"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30325-3"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002573"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.36.3.1046"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.10.021"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-10-201205150-00004"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2020.106227"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01600-z"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200601-003TK"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0062-2018"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.2021200279"},{"key":"e_1_2_14_31_1","first-page":"1","article-title":"CT quantification of the heterogeneity of fibrosis boundaries in idiopathic pulmonary fibrosis","volume":"13","author":"Park J","year":"2021","journal-title":"Eur Radiol"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112516"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0b013e3182a21969"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30433-2"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0560-x"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534666211004238"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/atm.ATM_230_20"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0986-4"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113354"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201809-1646OC"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202005-451OC"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.12.016"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00071004"},{"key":"e_1_2_14_44_1","first-page":"849035","article-title":"Effect and safety of mycophenolate mofetil in idiopathic pulmonary fibrosis","author":"Tzouvelekis A","year":"2011","journal-title":"Pulm Med"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16308-3"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1323"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0873-3529"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2012.48.10.1855760"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.708"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.02.036"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-6-201209180-00003"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.06.038"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15239-2"},{"key":"e_1_2_14_54_1","first-page":"S195","article-title":"Overview of idiopathic pulmonary fibrosis, evidence\u2010based guidelines, and recent developments in the treatment landscape","volume":"25","author":"Glassberg MK","year":"2019","journal-title":"Am J Manag Care"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.04.62"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0022-2019"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00026-2015"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60405-4"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402582"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0091OC"},{"key":"e_1_2_14_61_1","first-page":"218","article-title":"Real world experience of response to pirfenidone in patients with idiopathic pulmonary fibrosis: A two centre retrospective study","volume":"37","author":"Eaden JA","year":"2020","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.581828"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620963015"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1133"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01487-0"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00174914"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402584"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2020.7585\/2020"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/11795484211006050"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2018.06.003"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0558-x"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2020-000782"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03198-2020"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106369"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202007-901OC"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245147"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0021-2019"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.014"},{"key":"e_1_2_14_79_1","first-page":"741","article-title":"Lung transplantation in idiopathic pulmonary fibrosis: Risk factors and outcome","volume":"22","author":"Amor MS","year":"2020","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02413-2019"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.08.004"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.07.020"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12561"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2016.0170"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30502-2"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55100702"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081232"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1462704"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00220.2017"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02115-2016"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2020.104026"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00060014"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.05.002"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13456"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15378"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13382"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.08.055"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.04.060"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233732"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.021"},{"key":"e_1_2_14_101_1","first-page":"68","article-title":"Lung transplantation in idiopathic pulmonary fibrosis","volume":"6","author":"Laporta Hernandez R","year":"2018","journal-title":"Med Sci (Basel)"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030539"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29713"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37445"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201207-1204PP"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00142"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.061"},{"key":"e_1_2_14_108_1","first-page":"7568","article-title":"Intravenous stem cell dose and changes in quantitative lung fibrosis and DLCO in the AETHER trial: A pilot study","volume":"23","author":"Fishman JE","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0037"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.21"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1MR0114-068R"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-017-0214-z"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400281"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.11.6735"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.10.013"},{"key":"e_1_2_14_116_1","first-page":"5ra13","article-title":"Serum amyloid P inhibits fibrosis through Fc gamma R\u2010dependent monocyte\u2010macrophage regulation in vivo","volume":"1","author":"Casta\u00e3o AP","year":"2009","journal-title":"Sci Transl Med"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00366.x"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30173-0"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00850-2015"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2010.23.5.1444206"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1534OC"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093730"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2013.01.008"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.6129"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30172-9"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-5-S1-S24"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2019-000668"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30262-0"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-019-00542-6"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1773790"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020964451"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00180"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00032"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0004OC"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0235ED"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1685"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00755-3"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2019-000422"},{"key":"e_1_2_14_139_1","unstructured":"https:\/\/www.clinicaltrialsarena.com\/comment\/gilead-galapagos-discontinue-ipf-front-runner\/accessed April 21 2021"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2021.1867106"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03603-0"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02559-2020"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901995R"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25828"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30380"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1983"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00451.2020"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.595811"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.01.023"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1190-z"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504763"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0924-7"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01410-3"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01801-0"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.03.017"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103325"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0546OC"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01682-3"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.13466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T22:58:21Z","timestamp":1693177101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":157,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/crj.13466"],"URL":"https:\/\/doi.org\/10.1111\/crj.13466","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"2021-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}