{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:58:19Z","timestamp":1792432699700,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Severe viral pneumonia is associated with significant morbidity and mortality. Recent COVID\u201019 pandemic continues to impose significant health burden worldwide, and individual pandemic waves often lead to a large surge in the intensive care unit (ICU) admissions for respiratory support. Comparisons of severe SARS\u2010CoV\u20102 pneumonia with other seasonal and nonseasonal severe viral infections are rarely studied in an intensive care setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study comparing patients admitted to ICU with COVID\u201019 between March and June 2020 and those with viral pneumonias between January and December 2019. We compared patient specific demographic variables, duration of illness, ICU organ supportive measures and outcomes between both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis of 93 COVID\u201019 (Group 1) and 52 other viral pneumonia patients (Group 2) showed an increased proportion of obesity (42% vs. 23%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), non\u2010White ethnicities (41% vs. 6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and diabetes mellitus (30% vs. 13%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) in Group 1, with lower prevalence of chronic obstructive pulmonary disease (COPD)\/asthma (16% vs. 34%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). In Group 1, the neutrophil to lymphocyte ratio was much lower (6.7 vs. 10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), and invasive mechanical ventilation (58% vs. 26%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) was more common. Length of ICU (8 vs. 4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and hospital stay (22 vs. 11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) was prolonged in Group 1, with no significant difference in mortality. Influenza A and rhinovirus were the most common pathogens in Group 2 (26% each).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Key differences were identified within demographics (obesity, ethnicity, age, ICU scores, comorbidities) and organ support. Despite these variations, there were no significant differences in mortality between both groups. Further studies with larger sample sizes would allow for further assessment of clinical parameters in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.13482","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:12:38Z","timestamp":1645704758000},"page":"301-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Severe COVID\u201019 pneumonia in an intensive care setting and comparisons with historic severe viral pneumonia due to other viruses"],"prefix":"10.1111","volume":"16","author":[{"given":"Kiran","family":"Dadhwal","sequence":"first","affiliation":[{"name":"General Intensive Care Unit University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind","family":"Stonham","sequence":"additional","affiliation":[{"name":"General Intensive Care Unit University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Breen","sequence":"additional","affiliation":[{"name":"Department of Microbiology University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Poole","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Hospital Southampton University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0123-0302","authenticated-orcid":false,"given":"Kordo","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Microbiology University Hospital Southampton NHS Foundation Trust  Southampton UK"},{"name":"Faculty of Medicine, University Hospital Southampton University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahilanandan","family":"Dushianthan","sequence":"additional","affiliation":[{"name":"General Intensive Care Unit University Hospital Southampton NHS Foundation Trust  Southampton UK"},{"name":"Faculty of Medicine, University Hospital Southampton University of Southampton  Southampton UK"},{"name":"NIHR Southampton Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"The Intensive Care SocietyRecovery and restitution of ICU.https:\/\/www.ics.ac.uk\/ICS\/Pdfs\/COVID-19\/Recovery_and_Restitution_of_ICU. 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