{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:46:49Z","timestamp":1790650009877,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008309","name":"Hengityssairauksien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007634","name":"Ida Montinin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004182","name":"Nordisk Ministerr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010113","name":"Wilhelm och Else Stockmanns Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010113","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Smoking, exposure to environmental tobacco smoke (ETS) and occupational exposure to vapours, gases, dusts or fumes (VGDF) increase asthma symptoms. The impact of combined exposure is less well established. We aimed to evaluate the risk of combined exposure to smoking, ETS and VGDF on the prevalence of current asthma and asthma\u2010related symptoms with a postal survey among a random population of 16,000 adults, aged 20\u201369\u2009years (response rate 51.5%). The 836 responders with physician\u2010diagnosed asthma were included in the analysis. Of them, 81.9% had current asthma defined as physician\u2010diagnosed asthma with current asthma medication use or reported symptoms. There was a consistently increasing trend in the prevalence of current asthma by increased exposure. The highest prevalence of multiple symptoms was in smokers with VGDF exposure (92.1%) compared to the unexposed (73.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). In logistic regression analysis, combined exposure to several exposures increased the risk in all analysed symptoms (<jats:italic>p<\/jats:italic>\u2009=\u20090.002\u20130.007). In conclusion, smoking and exposure to ETS or VGDF increased the prevalence of current asthma and multiple symptoms. The combined exposure carried the highest risk. Preventive strategies are called for to mitigate exposure to tobacco smoke and VGDF.<\/jats:p>","DOI":"10.1111\/crj.13512","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T07:04:59Z","timestamp":1654844699000},"page":"467-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The combined effect of exposures to vapours, gases, dusts, fumes and tobacco smoke on current asthma"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-0279","authenticated-orcid":false,"given":"Hanna","family":"Hisinger\u2010M\u00f6lk\u00e4nen","sequence":"first","affiliation":[{"name":"University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kankaanranta","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sein\u00e4joki Central Hospital  Sein\u00e4joki Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Krefting Research Centre, Institute of Medicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tari","family":"Haahtela","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital, Helsinki University Hospital University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anssi","family":"Sovij\u00e4rvi","sequence":"additional","affiliation":[{"name":"University of Helsinki  Helsinki Finland"},{"name":"Unit of Clinical Physiology, HUS Medical Imaging Center Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Tuomisto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sein\u00e4joki Central Hospital  Sein\u00e4joki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-5865","authenticated-orcid":false,"given":"Heidi","family":"Anders\u00e9n","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit, Tema Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Clinical Research Unit of Pulmonary Diseases Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Backman","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Section for Sustainable Health\/the OLIN Unit Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulf","family":"Langhammer","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology  Levanger Norway"},{"name":"Levanger Hospital Nord\u2010Tr\u00f8ndelag Hospital Trust  Levanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"R\u00f6nmark","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Section for Sustainable Health\/the OLIN Unit Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinja","family":"Ilmarinen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sein\u00e4joki Central Hospital  Sein\u00e4joki Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Pallasaho","sequence":"additional","affiliation":[{"name":"Welfare and Health Sector  City of Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Piiril\u00e4","sequence":"additional","affiliation":[{"name":"University of Helsinki  Helsinki Finland"},{"name":"Unit of Clinical Physiology, HUS Medical Imaging Center Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2678"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000195"},{"issue":"8","key":"e_1_2_11_4_1","first-page":"1023","article-title":"Adolescent smokers are at greater risk for current asthma and rhinitis","volume":"13","author":"G\u00f3mez M","year":"2009","journal-title":"Int J Tuberc Lung Dis off J Int Union Tuberc Lung Dis"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00073312"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed\u20102016\u2010103595"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00850\u20102016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.03.036"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00116903"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00073712"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102222.2006.02486.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00143710"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201048484\u20108"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.008"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00075614"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00100102"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1301758"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.830095"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00191\u20102019"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.07.014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954\u20106111(99)90265\u20102"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201110\u20101917OC"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.06.021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9901033"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051033"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01857\u20102019"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2008.040022"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243826"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010020\u201001503\u2010z"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2010.058065"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106017"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.13512","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:08:15Z","timestamp":1692817695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/crj.13512"],"URL":"https:\/\/doi.org\/10.1111\/crj.13512","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2022-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}