{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:49:39Z","timestamp":1788817779433,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COPD prevalence in Denmark is estimated at 18% based on data from urban populations. However, studies suggest that using the clinical cut\u2010off for airway obstruction in population studies may overestimate prevalence. The present study aims to compare estimated prevalence of airway obstruction using different cut\u2010offs and to present lung function data from the Lolland\u2010Falster Health Study, set in a rural\u2010provincial area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Descriptive analysis of participant characteristics and self\u2010reported respiratory disease and of spirometry results in the total population and in subgroups defined by these characteristics. Airway obstruction was assessed using previously published Danish reference values and defined according to either FEV<jats:sub>1<\/jats:sub>\/FVC below lower limit of normal (LLN) 5% (as in clinical diagnosis) or 2.5% (suggested for population studies), or as FEV<jats:sub>1<\/jats:sub>\/FVC\u2009&lt;\u200970%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using either FEV<jats:sub>1<\/jats:sub>\/FVC\u2009&lt;\u200970% or LLN 5% cut\u2010off, 19.0% of LOFUS participants aged 35\u2009years or older had spirometry, suggesting airway obstruction. By the LLN 2.5% criterion, the proportion was considerably lower, 12.2%. The prevalence of airway obstruction was higher among current smokers, in participants with short education or reporting low leisure\u2010time physical activity and in those with known respiratory disease. Approximately 40% of participants reporting known respiratory disease had normal spirometry, and 8.7% without known respiratory disease had airway obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prevalence of airway obstruction in this rural population was comparable to previous estimates from urban Danish population studies. The choice of cut\u2010off impacts the estimated prevalence, and using the FEV<jats:sub>1<\/jats:sub>\/FVC cut\u2010off may overestimate prevalence. However, many participants with known respiratory disease had normal spirometry in this health study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13536","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T06:04:33Z","timestamp":1662185073000},"page":"657-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lung function in Lolland\u2010Falster Health Study (LOFUS)"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0680-9631","authenticated-orcid":false,"given":"Katja Kemp","family":"Jacobsen","sequence":"first","affiliation":[{"name":"Department of Technology, Faculty of Health and Technology University College Copenhagen  Copenhagen Denmark"},{"name":"Centre for Epidemiological Research Nyk\u00f8bing Falster Hospital  Nyk\u00f8bing Falster Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-9850","authenticated-orcid":false,"given":"Randi","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Centre for Epidemiological Research Nyk\u00f8bing Falster Hospital  Nyk\u00f8bing Falster Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uffe","family":"Bodtger","sequence":"additional","affiliation":[{"name":"Pulmonary Research Unit Region Zealand (PLUZ), Department of Respiratory Medicine Naestved Hospital  Naestved Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Internal Medicine Zealand University Hospital Roskilde  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knud","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Data and Development Support Region Zealand  Sor\u00f8 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gry","family":"St\u2010Martin","sequence":"additional","affiliation":[{"name":"Centre for Epidemiological Research Nyk\u00f8bing Falster Hospital  Nyk\u00f8bing Falster Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(20)30105\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411532"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(06)68516\u20104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1977.115.2.195"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.839647"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.062802"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.09.019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00110\u20102017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.07188"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00103309"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010020\u201010108\u20106"},{"key":"e_1_2_11_13_1","unstructured":"Danmarks statistik.Statistikbanken.https:\/\/www.statistikbanken.dk\/statbank5a\/default.asp?w=1920. 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