{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:38:02Z","timestamp":1774543082203,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002462","name":"Chungnam National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Macrolide\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>Mycoplasma pneumoniae<\/jats:italic><\/jats:styled-content> (MRMP) has become prevalent in children. This study investigated the clinical and laboratory variables of MRMP and macrolide\u2010sensitive <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content> (MSMP) and identified factors associated with prolonged hospital admission in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective multicenter study was conducted in 1063 children &lt;18\u2009years old in July 2018\u2013June 2020. The 454 had a positive <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content> polymerase chain reaction assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most subjects had MRMP (78.4%), and all mutated strains had the A2063G transition. We defined MRMP* (<jats:italic>n<\/jats:italic>\u2009=\u2009285) as MRMP pneumonia requiring admission and MSMP* (<jats:italic>n<\/jats:italic>\u2009=\u200972) as MSMP pneumonia requiring admission. Patients with MRMP pneumonia were older, more likely to have segmental\/lobar pneumonia, and had more febrile days than those with MSMP pneumonia. C\u2010reactive protein (CRP), lactate dehydrogenase (LDH), and percentage neutrophils were more strongly associated with MRMP* than MSMP* groups. Percentage neutrophils, CRP, and alanine aminotransferase significantly changed between admission and follow\u2010up measurements in patients with MRMP* (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The duration of admission positively correlated with the number of febrile days after initiation of antibiotic medication and laboratory variables (white blood cell count, CRP, and aspartate aminotransferase [AST]) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Random forest analysis indicated that the number of febrile days after initiation of antibiotic medication, AST, and percentage neutrophils at admission was over five.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study indicated that children with <jats:styled-content style=\"fixed-case\"><jats:italic>M. pneumoniae<\/jats:italic><\/jats:styled-content> pneumonia with a higher number of febrile days after initiation of antibiotic medication, AST, and percentage neutrophils at admission were more likely to have prolonged admission duration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13549","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T08:37:23Z","timestamp":1665131843000},"page":"756-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of variables associated with prolonged admission duration in children with <scp><i>Mycoplasma pneumoniae<\/i><\/scp> pneumonia"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-286X","authenticated-orcid":false,"given":"Myongsoon","family":"Sung","sequence":"first","affiliation":[{"name":"Department of Pediatrics Soonchunhyang University Hospital  Gumi South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui Jeong","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungnam National University Hospital  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sil","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungnam National University Hospital  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Chuncheon Sacred Heart Hospital  Chuncheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo\u2010Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inje University Sanggye Paik Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngmin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Eulji University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Wook","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Eulji University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kangwon National University School of Medicine  Chuncheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pusan National University Children's Hospital, Pusan National University School of Medicine  Yangsan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Su","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pusan National University Children's Hospital, Pusan National University School of Medicine  Yangsan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chungnam University Sejeong Hospital Chungnam National University College of Medicine  Sejong South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Kyeong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dongguk University Ilsan Hospital  Goyang South 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0145-7067","authenticated-orcid":false,"given":"Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chonnam National University Hostpital, Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Seok","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine, Chosun University, Chosun University Hospital, Gwangju, South Korea  Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Min","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Presbyterian Medical Center  Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meeyong","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Soonchunhyang University Bucheon Hospital  Bucheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Lee","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daegu Catholic University Medical Center  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daegu Catholic University Medical Center  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine, Kyungpook National University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeona","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine, Kyungpook National University  Daegu South 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