{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:56:19Z","timestamp":1747184179528,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Chronic obstructive pulmonary disease (COPD) is associated with many health complications, including pulmonary hypertension (PH). Although oral calcium channel blockers have shown promising results in managing COPD\u2010induced PH, significant systemic side effects may limit their use in this population. Administering verapamil through nebulization can be an alternative approach. We aim to assess the possible therapeutic effects of verapamil inhalation in out\u2010patients with pulmonary hypertension (PH) secondary to COPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind, randomized placebo\u2010controlled clinical trial was conducted. Patients with PH were randomly assigned to two groups of 15 participants. The intervention group received a short\u2010term single dose of 10\u00a0mg nebulized verapamil (4 ampoules of 2.5\u00a0mg\/ml verapamil solutions). The control group received nebulized distilled water as a placebo in addition to their standard treatment throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Systolic pulmonary artery pressure (sPAP) did not improve as a primary outcome significantly in patients receiving nebulized verapamil compared with those on placebo (<jats:italic>p<\/jats:italic>\u2009=\u20090.89). Spirometry results showed a significant improvement in FVC in the intervention group from 1.72\u2009\u00b1\u20090.63 to 1.85\u2009\u00b1\u20090.58\u00a0L (<jats:italic>p<\/jats:italic>\u2009=\u20090.00), and FEV1\/FVC ratio decreased significantly after verapamil administration (<jats:italic>p<\/jats:italic>\u2009=\u20090.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Verapamil did not improve any of the pulmonary artery or RV parameters in patients with COPD\u2010associated, but it did improve SpO<jats:sub>2<\/jats:sub> and increase FVC, which revealed us possibility of verapamil in treating V\/Q mismatch. The improved gas exchange may have been due to improvements in FVC as reflected in the improved spirometry. Higher doses of verapamil may be more efficacious and can be the subject of future trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13551","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T04:02:56Z","timestamp":1667793776000},"page":"802-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical evaluation of nebulized verapamil in out\u2010patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-1846","authenticated-orcid":false,"given":"Fanak","family":"Fahimi","sequence":"first","affiliation":[{"name":"American Career College  Anaheim USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guitti","family":"Pourdowlat","sequence":"additional","affiliation":[{"name":"Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Behzadnia","sequence":"additional","affiliation":[{"name":"Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar Sadigh","family":"Mostofi","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida Sefidani","family":"Forough","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, Faculty of Health Queensland University of Technology (QUT)  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Parto","sequence":"additional","affiliation":[{"name":"Concorde Career College  Garden Grove California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-0248","authenticated-orcid":false,"given":"Ayda","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Experimental and Applied Pharmaceutical Sciences Research Center Urmia University of Medical Sciences  Urmia Iran"},{"name":"Department of Clinical Pharmacy, School of Pharmacy Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","first-page":"669","article-title":"Morphometric study in chronic obstructive bronchopulmonary disease. 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