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All articles related from January 2019 to May 2022 were reviewed. The STATA software was used for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk of death in COVID\u201019 patients with chronic liver disorders was higher than in ones without the chronic liver disease (RR: 1.52; CI 95%: 1.46\u20131.57; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 86.14%). Also, the risk of acute respiratory distress syndrome (ARDS) and hospitalization in COVID\u201019 patients with chronic liver disorders was higher than in ones without the chronic liver disease ([RR: 1.65; CI 95%: 1.09\u20132.50; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 0.00%] and [RR: 1.39; CI 95%: 1.23\u20131.58; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 0.20%]). Also, the meta\u2010analysis showed cough, headache, myalgia, nausea, diarrhea, and fatigue were 1.37 (CI 95%: 1.20\u20131.55), 1.23 (CI 95%: 1.09\u20131.38), 1.25 (CI 95%: 1.04\u20131.50), 1.19 (CI 95%: 1.02\u20131.40), 1.89 (CI 95%: 1.30\u20132.75), 1.49 (CI 95%: 1.07\u20132.09), and 1.14 (CI 95%: 0.98\u20131.33), respectively, whereas the risk of all these symptoms was higher in COVID\u201019 patients with chronic liver diseases than ones without chronic liver disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mortality and complications due to COVID\u201019 were significantly different between patients with the chronic liver disease and the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13552","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T08:34:52Z","timestamp":1666082092000},"page":"777-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID\u201019: A systematic review and meta\u2010analysis of cohort studies"],"prefix":"10.1111","volume":"16","author":[{"given":"Maryam","family":"Afraie","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medicine Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pardis","family":"Mohammadzedeh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medicine Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mobin","family":"Azami","sequence":"additional","affiliation":[{"name":"Student Research Committee Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorour","family":"Khateri","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Hamedan University of Medical Sciences  Hamedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Zamani","sequence":"additional","affiliation":[{"name":"Student Research Committee Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Moradpour","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Research Institute for Health Development Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-5930","authenticated-orcid":false,"given":"Yousef","family":"Moradi","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Research Institute for Health Development Kurdistan University of Medical Sciences  Sanandaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"volume-title":"Chronic Liver Disease. 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