{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:34:10Z","timestamp":1792020850573,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic obstructive pulmonary disease (COPD) has been reported as a potential risk factor for developing herpes zoster (HZ). We aimed at comparing incidence rates of HZ between people with versus without COPD in the US. This retrospective cohort study used data from Optum's de\u2010identified Clinformatics Data Mart database from 1\/1\/2013 through 12\/31\/2018. We identified two cohorts of people \u226540\u2009years without prior HZ, HZ vaccination, postherpetic neuralgia (PHN) or HZ ophthalmicus: those with (COPD+) and those without (COPD\u2212) a COPD diagnosis. Adjusted incidence rate ratios (aIRRs) of HZ and PHN were calculated using generalized linear models, controlling for the propensity score of being diagnosed with COPD and relevant demographic and clinical characteristics. People in the COPD+ cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009161\u2009970) were considerably older, had more comorbidities and were more likely to use corticosteroids than those in the COPD\u2212 cohort (<jats:italic>n<\/jats:italic>\u2009=\u20099\u2009643\u2009522). The incidence rate of HZ was 5.7\u2010fold higher in the COPD+ versus COPD\u2212 cohorts (13.0 vs. 2.3 per 1000 person\u2010years [PY]; aIRR, 2.77; 95% confidence interval [CI], 2.69 to 2.85; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The unadjusted incidence rate of PHN was 1.7\u2010fold higher in the COPD+\/HZ+ versus COPD\u2212\/HZ+ cohort (64.8 vs. 37.1 per 1000 PY), but not after adjustment (aIRR, 1.07; 95% CI, 0.79 to 1.45). HZ and PHN incidence rates increased with age. After adjustment, COPD+ adults had a 2.8\u2010fold increased risk of developing HZ. These results may help to increase awareness about potential risk factors for HZ and highlight the need for vaccination among those at increased risk.<\/jats:p>","DOI":"10.1111\/crj.13554","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T07:56:08Z","timestamp":1669190168000},"page":"826-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chronic obstructive pulmonary disease is associated with an increased risk of herpes zoster: A retrospective United States claims database analysis"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-3941","authenticated-orcid":false,"given":"Philippe","family":"Thompson\u2010Leduc","sequence":"first","affiliation":[{"name":"Health Economics and Outcomes Research Analysis Group, Inc.  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parinaz","family":"Ghaswalla","sequence":"additional","affiliation":[{"name":"US Health Outcomes and Epidemiology \u2013 Vaccines, GSK  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy Y.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research Analysis Group, Inc  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Jung","family":"Wang","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research Analysis Group, Inc  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bogart","sequence":"additional","affiliation":[{"name":"Value Evidence and Outcomes, GSK  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon J.","family":"Patterson","sequence":"additional","affiliation":[{"name":"US Health Outcomes and Epidemiology \u2013 Vaccines, GSK  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Sheng","family":"Duh","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research Analysis Group, Inc  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suna","family":"Park","sequence":"additional","affiliation":[{"name":"Health Economics and Outcomes Research Analysis Group, Inc  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara P.","family":"Yawn","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.1.70\u201080.2005"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"S2","article-title":"The burden of herpes zoster and postherpetic neuralgia in the United States","volume":"107","author":"Weaver BA","year":"2007","journal-title":"J Am Osteopath Assoc"},{"key":"#cr-split#-e_1_2_10_4_1.1","unstructured":"Centers for Disease Control and Prevention (CDC) [Internet].Washington (DC): U.S. Department of Health & Human Services. 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