{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:07:35Z","timestamp":1790806055877,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Tuberculosis (TB) patients who develop venous thromboembolism (VTE) have poor clinical outcomes. This study aimed to explore the risk factors and the prognosis of TB patients with VTE. A total of 11\u2009267 with TB patients from the Zhejiang University\u2010affiliated Chest Hospital, China, were enrolled between January 2016 and January 2020. A total of 107\u2009TB patients with VTE were selected as the VTE group. Patients in the control group were randomly screened in a 1:1 ratio between the VTE and control groups. Univariate and multivariate logistic regression analysis was used to evaluate the factors associated with VTE in TB patients. Of the 214 patients, 145 (60.17%) were male, 69 (32.2%) were female, with an average age of 62.21\u2009\u00b1\u200919.35. The incidence of VTE in TB patients was 0.95%. Using a univariate analysis, it was found that age, fever, dyspnea, lower limb edema, respiratory failure, malignant tumor, prothrombin time, activated partial thromboplastin time, D\u2014dimer, and hemoglobin levels were different between the two groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate logistic regression analysis showed that higher D\u2010dimer value, higher incidence of lower limb edema, and TB were risk factors for VTE; OR (95%CI)\u2009=\u20098.840 (2.383\u201332.794); OR (95%CI)\u2009=\u20094.957 (1.219\u201320.161); OR (95%CI)\u2009=\u200916.216 (4.779\u201355.025). However, the use of Rifamycin was found to be a protective factor against VTE [OR (95%CI) =\u20090.170(0.073\u20130.395)]. Receiver operating characteristic curve (ROC) curve of D\u2010dimer (area under curve [AUC]\u2009=\u20090.831\u2009\u00b1\u20090.028 [95%CI: 0.776\u20130.886, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05]) and the cut\u2010off value of 1855\u2009\u03bcg\/L was obtained according to the Youden index, with a sensitivity and a specificity rate of 82.2% and 74.3%, respectively. The risks of VTE seem higher in TB patients with fever, dyspnea, lower limb edema, and D\u2010dimer levels of more than 1855\u2009\u03bcg\/L; therefore, it should be actively screened, and prophylactic anticoagulation given if necessary. Effective directly observed treatment plus short\u2010course chemotherapy (DOTS) protocol anti\u2010TB therapy helps reduce the probability of VTE in TB patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13555","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T03:53:57Z","timestamp":1667879637000},"page":"835-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk factors associated with venous thromboembolism in tuberculosis: A case control study"],"prefix":"10.1111","volume":"16","author":[{"given":"Guo Yi","family":"Nan","sequence":"first","affiliation":[{"name":"Department of Tuberculosis, Affiliated Hangzhou Chest Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Respiratory diseases, Affiliated Hangzhou Chest Hospital Zhejiang University School of Medicinel  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of medical quality control, Affiliated Hangzhou Chest Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan Tian","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.83"},{"key":"e_1_2_11_3_1","first-page":"2020","author":"WHO","year":"2020","journal-title":"Global TB 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Respiration"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102141.2001.03061.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.10.006"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(89)90603\u2010X"}],"container-title":["The Clinical Respiratory 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