{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:11:05Z","timestamp":1776705065353,"version":"3.51.2"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>High flow nasal cannula (HFNC) reduces the need for intubation in patients with hypoxaemic acute respiratory failure (ARF), but its added value in patients with severe coronavirus disease 2019 (COVID\u201019) and a do\u2010not\u2010intubate (DNI) order is unknown. We aimed to assess (variables associated with) survival in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We described a multicentre retrospective observational cohort study in five hospitals in the Netherlands and assessed the survival in COVID\u201019 patients with severe acute respiratory failure and a DNI order who were treated with high flow nasal cannula. We also studied variables associated with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>One\u2010third of patients survived after 30\u2009days. Survival was 43.9% in the subgroup of patients with a good WHO performance status and only 16.1% in patients with a poor WHO performance status. Patients who were admitted to the hospital for a longer period prior to HFNC initiation were less likely to survive. HFNC resulted in an increase in ROX values, reflective of improved oxygenation and\/or decreased respiratory rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that a trial of HFNC could be considered to increase chances of survival in patients with ARF due to COVID\u201019 pneumonitis and a DNI order, especially in those with a good WHO performance status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13573","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T18:23:16Z","timestamp":1672424596000},"page":"115-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High flow nasal cannula for acute respiratory failure due to COVID\u201019 in patients with a \u2018do\u2010not\u2010intubate\u2019 order: A survival analysis"],"prefix":"10.1111","volume":"17","author":[{"given":"Illaa","family":"Smesseim","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC Free University Amsterdam and University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Mooij\u2010Kalverda","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC Free University Amsterdam and University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Hessels","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Noordwest Ziekenhuisgroep  Alkmaar The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Korevaar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC Free University Amsterdam and University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Atasever","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Spaarne Gasthuis  Haarlem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hjalmar","family":"de Graaff","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Onze Lieve Vrouwe Gasthuis  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Goorhuis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Nossent","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC Free University Amsterdam and University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences Research Institute, Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieuwe","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC Free University Amsterdam and University of Amsterdam  Amsterdam The Netherlands"},{"name":"Intensive Care Amsterdam University Medical Centers\u2014location AMC  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bonta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC Free University Amsterdam and University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Amsterdam UMC HFNC study group:","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost","family":"van den Aardweg","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC Free University Amsterdam and University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Noordwest Ziekenhuisgroep  Alkmaar The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"van der Lee","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Spaarne Gasthuis  Haarlem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herre J.","family":"Reesink","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Onze Lieve Vrouwe Gasthuis  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01154\u20102020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.52"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010020\u201006228\u20107"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00048\u20102021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.05.022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08631"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02130\u20102020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010021\u201003599\u20101"},{"key":"e_1_2_10_10_1","volume-title":"Principles and Practice of Mechanical 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