{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T05:02:08Z","timestamp":1692766928438},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010486","name":"Teijin Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010486","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical features of asthma with connective tissue diseases (CTDs) are not well\u2010known. This study therefore aimed to investigate the clinical characteristics of asthma with CTDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined the records of adults (\u226518\u2009years old) with asthma followed up between January 2010 and December 2019. We then compared the clinical features of asthma with and without CTDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 568 subjects with asthma, 42 subjects (7.4%) had CTDs. The most frequent concomitant CTD was rheumatoid arthritis (<jats:italic>n<\/jats:italic>\u2009=\u200923, 54.8%), followed by systemic lupus erythematosus (<jats:italic>n<\/jats:italic>\u2009=\u20096, 14.3%). The proportion of women (with vs. without CTDs, 85.7% vs. 56.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and Global Initiative for Asthma step were higher (Step 4 or 5, with vs. without CTDs, 81.0% vs. 62.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) in asthma with CTDs, whereas frequency of allergic rhinitis was higher in asthma without CTDs (with vs. without CTDs, 7.1% vs. 26.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). Eosinophil ratio (with vs. without CTDs, 2.1% vs. 3.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.009) and total immunoglobulin E level (with vs. without CTDs, 43\u2009IU\/mL vs. 237\u2009IU\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) were lower in asthma with CTDs. In terms of lung function, percentage predicted forced vital capacity (with vs. without CTDs, 86.7% vs. 99.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) and percentage predicted forced expiratory volume in 1\u00a0s (%FEV1) (with vs. without CTDs, 77.2% vs. 88.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) were all lower in asthma with CTDs. With multivariable analysis, CTDs (odds ratio [OR] 2.8, 95%CI 1.3\u20136.0; <jats:italic>p<\/jats:italic>\u2009=\u20090.008), chronic obstructive pulmonary disease (OR 3.8, 95%CI 2.1\u20136.7; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and asthma onset at &lt;20\u2009years old (OR 1.8, 95%CI 1.1\u20133.2; <jats:italic>p<\/jats:italic>\u2009=\u20090.03) were associated with low FEV1 (defined as %FEV1 &lt;\u200980%) in asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Asthma with CTDs was related to lower lung function and low\u2010T2 inflammation asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13595","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:14:06Z","timestamp":1676744046000},"page":"303-310","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical features of asthma with connective tissue 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