{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:34:29Z","timestamp":1790638469852,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI135108"],"award-info":[{"award-number":["AI135108"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL095021"],"award-info":[{"award-number":["HL095021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cytomegalovirus (CMV) seropositivity has been recently linked to severity and progression of asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). To date, no longitudinal study has addressed the relation of CMV serology to levels and decline of lung function in the general adult population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 403 participants from the Tucson Epidemiological Study of Airway Obstructive Disease (TESAOD) who at enrollment were aged 28\u201355\u2009years and completed lung function tests. During follow\u2010up, the 403 participants completed on average 7.2 lung function tests per subject for a total of 2908 observations over a mean period of 14.7\u2009years. We tested CMV serology in serum samples from enrollment and categorized participants into low, medium, and high CMV serology based on tertiles. The relation of CMV serology at enrollment to lung function levels and decline during follow\u2010up was tested in multivariate random coefficients models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After full adjustment, participants in the highest CMV serology tertile had faster declines of forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>) and FEV<jats:sub>1<\/jats:sub>\/forced vital capacity (FVC) compared with subjects in the lowest tertile (by \u22127.9\u2009ml\/year 95% confidence interval [\u221213.9\u2009ml\/year, \u22121.93\u2009ml\/year], and by \u22120.13%\/year [\u22120.23%\/year, \u22120.026%\/year], respectively). These CMV effects were additive with those of cigarette smoking. No associations were found between CMV serology and FVC, indicating specific effects of CMV seropositivity on airflow limitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High CMV serology in young to mid\u2010adult life may be linked to increased COPD risk through an accelerated decline of lung function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13600","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T07:06:02Z","timestamp":1678950362000},"page":"468-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytomegalovirus serology in young to mid\u2010adult life and decline of lung function"],"prefix":"10.1111","volume":"17","author":[{"given":"Raffaella","family":"Nenna","sequence":"first","affiliation":[{"name":"Asthma and Airway Disease Research Center University of Arizona  Tucson Arizona USA"},{"name":"Department of Maternal Infantile and Urological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhai","sequence":"additional","affiliation":[{"name":"Asthma and Airway Disease Research Center University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Spangenberg","sequence":"additional","affiliation":[{"name":"Asthma and Airway Disease Research Center University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane L.","family":"Sherrill","sequence":"additional","affiliation":[{"name":"Asthma and Airway Disease Research Center University of Arizona  Tucson Arizona USA"},{"name":"Mel and Enid Zuckerman College of Public Health University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando D.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Asthma and Airway Disease Research Center University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Halonen","sequence":"additional","affiliation":[{"name":"Asthma and Airway Disease Research Center University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7218-3246","authenticated-orcid":false,"given":"Stefano","family":"Guerra","sequence":"additional","affiliation":[{"name":"Asthma and Airway Disease Research Center University of Arizona  Tucson Arizona USA"},{"name":"Department of Medicine, College of Medicine \u2013 Tucson University of Arizona  Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01727\u20102018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.2021.0221"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00062\u20102020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701\u20100218PP"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411532"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.5.717"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.4.413"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.4.2645"},{"issue":"6","key":"e_1_2_9_12_1","first-page":"1530","article-title":"Cytomegalovirus induces Interleukin\u20106 mediated inflammatory response in salivary gland cancer","volume":"21","author":"Radunovic M","year":"2016","journal-title":"J BUON"}],"container-title":["The Clinical Respiratory 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