{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:58:15Z","timestamp":1792645095649,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The pathogenesis of non\u2010cystic fibrosis bronchiectasis has not been clearly clarified. This study aimed to investigate the expression of ciliary regulating protein forkhead box protein j1 (Foxj1) on airway epithelium in non\u2010cystic fibrosis bronchiectasis and its association with airway cilia structure disorder and disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lung tissue sections excised from 47 patients with non\u2010cystic fibrosis bronchiectasis were included between January 2018 and June 2021. Specimens from 26 subjects who underwent a lobectomy due to lung nodule were chosen as controls. Clinical information was collected, and pathologic analysis was performed to assess the epithelial structure and expression of ciliary regulating Foxj1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 47 patients with non\u2010cystic fibrosis bronchiectasis, 25 were considered as mild, 12 were moderate whereas the remaining 10 cases were severe according to the bronchiectasis severity index score evaluation. Epithelial hyperplasia, hyperplasia of goblet cells and inflammatory cell infiltration were observed in non\u2010cystic fibrosis bronchiectasis, compared with control subjects. Cilia length in non\u2010cystic fibrosis bronchiectasis patients were shorter than that in the control group, (5.34\u2009\u00b1\u20090.89)\u00a0\u03bcm versus (7.34\u2009\u00b1\u20090.71)\u00a0\u03bcm, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). The expression of Foxj1 was (2.69\u2009\u00b1\u20091.09)\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> in non\u2010cystic fibrosis bronchiectasis, compared with (6.67\u2009\u00b1\u20091.15)\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> in the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Moreover, patients with lower expression of Foxj1 showed shorter airway cilia and worse in disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Foxj1 declined in the airway epithelium of patients with non\u2010cystic fibrosis bronchiectasis, positively correlated to cilia length and might imply worse disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13605","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:14:10Z","timestamp":1679012050000},"page":"405-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Down\u2010expression of Foxj1 on airway epithelium with impaired cilia architecture in non\u2010cystic fibrosis bronchiectasis implies disease severity"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-8087","authenticated-orcid":false,"given":"Xiao\u2010Ling","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Third Affiliated Hospital of Sun Yat\u2010sen University, Institute of Respiratory Diseases of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Third Affiliated Hospital of Sun Yat\u2010sen University, Institute of Respiratory Diseases of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Wen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Third Affiliated Hospital of Sun Yat\u2010sen University, Institute of Respiratory Diseases of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Third Affiliated Hospital of Sun Yat\u2010sen University, Institute of Respiratory Diseases of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Third Affiliated Hospital of Sun Yat\u2010sen University, Institute of Respiratory Diseases of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Tuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Third Affiliated Hospital of Sun Yat\u2010sen University, Institute of Respiratory Diseases of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.09.011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303\u20100411CI"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010019\u20100818\u20106"},{"key":"e_1_2_11_7_1","first-page":"6","article-title":"Inflammation: a two\u2010edged sword\u2010the model of bronchiectasis","volume":"147","author":"Cole PJ","year":"1986","journal-title":"Eur J Respir Dis 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