{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:56:32Z","timestamp":1747184192302,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The metastases of lung cancer to bilateral choroids symmetrically and simultaneously are very rare. Almost all patients with choroid metastasis can be treated with external beam radiotherapy in order to increase quality of life and preserve vision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We documented a case and studied the effect of icotinib on choroidal metastases in bilateral eyes simultaneously from pulmonary adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 49\u2010year\u2010old Chinese man presented with bilateral vision losing simultaneously for 4\u2009weeks, it was as an initial presentation in the clinical. The examinations with ophthalmofundoscopy, ultrasonography, and fluorescein angiography showed the lesions in bilateral choroids, two solitary juxtapapillary yellow\u2010white choroidal metastases inferior to the optic discs with bleeding. Positron emission tomography confirmed the choroidal metastases and further proved that it was from lung cancer with lymph nodes and multiple bone metastasis. The biopsy taken from the lung by bronchoscopy and needle biopsy from supraclavicular lymph nodes revealed the pulmonary adenocarcinoma with epithelial growth factor receptor mutation (exon 21). The patient was treated with oral icotinib (125\u2009mg, three times a day, TID). Five\u00a0days after starting icotinib therapy, the patient's visions were rapidly recovered. Two months after the treatment with icotinib, the choroidal metastases regressed to small lesions, and the visions were preserved to before. The lung tumor and other metastatic lesions were partly regressive. There was no evidence of recurrence for eye lesions at 15\u2010months follow\u2010up. After 17\u2009months treating by icotinib, the patient presented headache and dizzy with multiple brain metastases determined by magnetic resonance imaging; however, the lesions of the choroidal metastases remained progressing\u2010free. Almonertinib with radiotherapy were used to treat the brain metastases, and he is surviving with progress\u2010free more than 2\u00a0years until now.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bilateral choroidal metastases from lung cancer symmetrically are very rare. Icotinib following by almonertinib was an alternative therapy for choroidal metastasis from non\u2010small cell lung cancer with epithelial growth factor receptor mutation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13649","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T23:13:45Z","timestamp":1686784425000},"page":"647-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rapid vision improvement by using icotinib in a patient with bilateral choroidal metastases symmetrically from lung cancer"],"prefix":"10.1111","volume":"17","author":[{"given":"Chaoran","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Xi'an International Medical Center Hospital  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue E","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Xi'an International Medical Center Hospital  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Xi'an International Medical Center Hospital  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yani","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Xi'an International Medical Center Hospital  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-7940","authenticated-orcid":false,"given":"Yun Kui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Xi'an International Medical Center Hospital  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025\u20106196(11)60735\u20100"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00312\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759\u20107714.14440"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1119\u20103077.212439"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2019.100992"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u2010620X.137159"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8488\u201016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2022.2066984"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"10","article-title":"Targeted lung cancer treatments and eye metastasis","volume":"6","author":"Zarogoulidis P","year":"2017","journal-title":"Med Hypothesis Discov Innov Ophthalmol"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:42:08Z","timestamp":1692319328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,14]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/crj.13649"],"URL":"https:\/\/doi.org\/10.1111\/crj.13649","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"type":"print","value":"1752-6981"},{"type":"electronic","value":"1752-699X"}],"subject":[],"published":{"date-parts":[[2023,6,14]]},"assertion":[{"value":"2023-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}