{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:42:23Z","timestamp":1793292143656,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obstructive sleep apnea (OSA) is one of the leading respiratory disorders, increasing the risk of cardiometabolic diseases. In the study, we investigated the association between OSA and the risk of cardiometabolic diseases and all\u2010cause and cardiovascular mortality in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were enrolled in the National Health and Nutrition Examination Survey. The baseline covariates were compared between participants with and without OSA status. Multivariable logistic regression was performed to explore the association between OSA and cardiometabolic diseases, while Cox proportional regression was performed for all\u2010cause and cardiovascular mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OSA status was positively associated with higher risks of cardiometabolic diseases, including hypertension (odds ratio [OR] 1.28, 95% confidence interval [CI] 1.14\u20131.45; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), diabetes (OR 1.46, 95% CI 1.22\u20131.76; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and cardiovascular diseases (OR 1.29, 95% CI 1.08\u20131.54; <jats:italic>p<\/jats:italic>\u2009=\u20090.006) after adjusting for numerous covariates. However, no associations of OSA with all\u2010cause or cardiovascular mortality were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OSA was associated with a higher risk of hypertension, diabetes, and cardiovascular diseases, but had no significant association with all\u2010cause or cardiovascular mortality in adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13666","type":"journal-article","created":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T05:30:36Z","timestamp":1690003836000},"page":"764-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association of obstructive sleep apnea with cardiometabolic diseases and cardiovascular mortality"],"prefix":"10.1111","volume":"17","author":[{"given":"Jia","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Jiangsu Province Official Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licheng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Jiangsu Province Official Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-2615","authenticated-orcid":false,"given":"Xuanfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Jiangsu Province Official Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Jiangsu Province Official Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7520"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19635"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.2180"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072\u20101439.2015.06.11"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(05)71141\u20107"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4654"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010014\u20100535\u2010y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5880"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010021\u201001445\u2010y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010018\u20100855\u20101"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023353"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.04.020"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2018.0256"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00278002"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27662"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201802\u2010136OC"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003270"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.76"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S148735"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712\u20101884OC"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.03.010"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102796.2001.00787.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072\u20101439.2012.01.06"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13\u20101163"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.10.943"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109718"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4327237"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137560"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2008"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy624"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00051504"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.8432"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010022\u201003587\u20102"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.08.009"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086051"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.02.013"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606599"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:57:02Z","timestamp":1692694622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,21]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/crj.13666"],"URL":"https:\/\/doi.org\/10.1111\/crj.13666","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,21]]},"assertion":[{"value":"2023-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}