{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:25:36Z","timestamp":1769153136929,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Effect of booster vaccination and vitamin D status on antibody production of Omicron variant\u2010infected adults need to be further explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, longitudinal, real\u2010world cohort study was performed. All included cases were divided into vitamin D deficiency (VDD) and non\u2010VDD (control) groups according to baseline serum 25\u2010hydroxyvitamin D [25(OH)D] concentration and then into unvaccinated, routinely vaccinated, and booster vaccinated VDD and control subgroups according to vaccination status. Antibody dynamics were observed within six time periods during hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 204 adult cases were included, of which 121 (59%) were males; 23 (11%), 31 (15%), and 26 (13%) or 50 (25%), 35 (17%), and 39 (19%) were unvaccinated, routinely vaccinated, and booster vaccinated VDD cases or controls, respectively. The median (interquartile range) for age and baseline 25(OH)D concentration was 42.5 (31\u201353.5) years and 21.5 (18\u201325.4) ng\/mL, respectively. The IgM titers within 3 to 7\u00a0days and 7 to 14\u2009days increased rapidly to 1.8\u2010fold (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 3.6\u2010fold (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) those within the first day; the IgG titers increased to 5.8\u2010fold (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 10.9\u2010fold (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Booster vaccinated controls had higher first IgG titers compared with unvaccinated controls (3.1\u2010fold; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) or booster vaccinated VDD cases (2.1\u2010fold; <jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Booster vaccination and non\u2010VDD status may have an interactive boosting effect on IgG production of Omicron variant\u2010infected adults. Further randomized clinical trials may be needed to determine whether booster vaccination combined with VDD correction improves the humoral immunity to Omicron variants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13694","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T10:35:04Z","timestamp":1694082904000},"page":"1067-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant\u2010infected adults: A real\u2010world cohort study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-4474","authenticated-orcid":false,"given":"Denggao","family":"Peng","sequence":"first","affiliation":[{"name":"Graduate Collaborative Training Base of Shenzhen Third People's Hospital, Hengyang Medical School University of South China  Hengyang 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to Southern University of Science and Technology  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Collaborative Training Base of Shenzhen Third People's Hospital, Hengyang Medical School University of South China  Hengyang China"},{"name":"Department of Infectious Diseases, Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology  Shenzhen 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