{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:23:17Z","timestamp":1782998597982,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["YJS20210374"],"award-info":[{"award-number":["YJS20210374"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) have different pathological and clinical features, they may share common driver genes. It was found that lipid levels can be used for early diagnosis of NSCLC; however, the relationship between driver genes and genes regulating lipid metabolism and their relationship with patient prognosis needs further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genes whose expression was up\u2010 or down\u2010regulated in both LUAD and LUSC were identified using the GEO database. Online tools like GEPIA 2, PrognoScan, UALCAN, and TIMER2.0 were used to investigate the association of these gene expressions with the patient's prognosis and lipid regulatory genes. The association between clinical lipid levels and the risk of LUAD and LUSC was analyzed by using a multiple logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topoisomerase II alpha (<jats:italic>TOP2A<\/jats:italic>) and alcohol dehydrogenase 1B (<jats:italic>ADH1B<\/jats:italic>) were identified as the only genes up\u2010 and down\u2010regulated in both LUAD and LUSC. <jats:italic>TOP2A<\/jats:italic> and <jats:italic>ADH1B<\/jats:italic> expression levels significantly correlated with the patient's gender, age, individual cancer stage, histological subtype, nodal metastasis status, and TP53 mutation status. Additionally, only LUAD patients with higher <jats:italic>TOP2A<\/jats:italic> or lower <jats:italic>ADH1B<\/jats:italic> expressions displayed poor overall and relapse\u2010free survival rates. Moreover, <jats:italic>TOP2A<\/jats:italic> levels exhibited a negative correlation with adipose triglyceride lipase (<jats:italic>ATGL<\/jats:italic>) and ATP\u2010binding cassette transporter A1 (<jats:italic>ABCA1<\/jats:italic>) in both LUAD and LUSC. However, <jats:italic>ADH1B<\/jats:italic> showed inverse associations with the above\u2010mentioned genes when compared to <jats:italic>TOP2A<\/jats:italic> expressions in both LUAD and LUSC. Furthermore, elevated triglyceride (OR\u2009=\u20091.59; 95% CI\u2009=\u20091.01 to 2.49; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and total cholesterol (OR\u2009=\u20092.45; 95% CI\u2009=\u20091.08 to 5.57; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) levels might increase the risk of LUAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>TOP2A<\/jats:italic> and <jats:italic>ADH1B<\/jats:italic> can be used as diagnostic markers for LUAD and LUSC, but only as independent prognostic factors for LUAD, and may be involved in lipid metabolism in LUAD patients but not in LUSC. Thus, combining genetic diagnostics with lipid panel tests might be an effective method for an early diagnosis and improved prognosis of LUAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13717","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T14:04:06Z","timestamp":1700575446000},"page":"1301-1315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of <i>TOP2A<\/i> and <i>ADH1B<\/i> with lipid levels and prognosis in patients with lung adenocarcinoma and squamous cell carcinoma"],"prefix":"10.1111","volume":"17","author":[{"given":"Dongdong","family":"Yin","sequence":"first","affiliation":[{"name":"First Affiliated Hospital (Huainan First People's Hospital) Anhui University of Science and Technology  Huainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinci","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital (Huainan First People's Hospital) Anhui University of Science and Technology  Huainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital (Huainan First People's Hospital) Anhui University of Science and Technology  Huainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-7588","authenticated-orcid":false,"given":"Longqiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital (Huainan First People's Hospital) Anhui University of Science and Technology  Huainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000703"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010020\u201001221\u20106"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.48322"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25183"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.19.7177"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.21824"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12204"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010021\u201002439\u20100"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.06.069"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.42736"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.877254"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22120"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgx067"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4920"},{"key":"e_1_2_11_17_1","first-page":"3","article-title":"Lipid metabolism and classification of hyperlipaemias. 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