{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:34:19Z","timestamp":1788266059168,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019FE001(\u201058)"],"award-info":[{"award-number":["2019FE001(\u201058)"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti\u2010melanoma differentiation\u2010associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IgG, IgA and IgM in the DM\u2010associated ILD (ILD\u2010DM) were higher than that of the DM non\u2010complicating ILD (Non\u2010ILD\u2010DM) (<jats:italic>p<\/jats:italic>\u00a0=\u20090.022, 0.002 and 0.029, respectively). Meanwhile, IL\u20106 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.008) and IL\u201010 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.001) were increased in the DM\u2010associated PH (PH\u2010DM) than in the DM non\u2010complicating PH (Non\u2010PH\u2010DM), while IL\u201017 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH\u2010DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5<jats:sup>+<\/jats:sup> DM) than that of the DM without MDA5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ILD\u2010DM has higher IgG, IgA and IgM than that of Non\u2010ILD\u2010DM. PH\u2010DM has higher IL\u20106, IL\u201010 and lower IL\u201017, DP cell ratio and B lymphocyte ratio than that of Non\u2010PH\u2010DM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.13720","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T14:02:17Z","timestamp":1700575337000},"page":"1328-1340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis"],"prefix":"10.1111","volume":"17","author":[{"given":"Chulin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital Kunming Medical University  Kunming China"},{"name":"Department of Anesthesiology Kunming Medical University  Kunming 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