{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:42:14Z","timestamp":1789569734362,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Asthma associated with obesity is a chronic disease characterized by earlier airway remodeling, severe wheezing, and increased insensitivity to hormone therapy. Reticuline, a bioactive compound of\n                      <jats:italic>Magnoliae Flos<\/jats:italic>\n                      , exerts anti\u2010inflammatory activity and can inhibit neutrophil recruitment. Thus, this study investigated the role of reticuline in obesity\u2010related asthma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The BALB\/c mice fed a low\u2010fat diet (LFD) and high\u2010fat diet (HFD) were intranasally challenged with house dust mites (HDMs) or ovalbumin (OVA). Reticuline (0.25\u2009mg\/kg) was administrated into mice by intragastrical gavage. Airway hyper\u2010responsiveness was examined after the final challenge. Body weight was measured, and bronchoalveolar lavage fluid (BALF) and lung tissues were collected. The number of inflammatory cells in BALF was estimated. Histological changes were assessed by performing hematoxylin\u2013eosin staining, and production of proinflammatory cytokines and IgE was examined by ELISA kits. Related pathways were studied with western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Reticuline suppressed airway resistance and inflammatory infiltration in lung tissue and reduced inflammatory cell recruitment in BALF in obesity mice with asthma. Additionally, the levels of IL\u201017A, IL\u20101\u03b2, IL\u20105, macrophage inflammatory protein 2, and regulated on activation, normal T cell expressed and secreted in the lung were reduced by reticuline. Mechanistically, reticuline inactivated the JAK2\/STAT3\/SOCS3 and p38 MAPK\/NF\u2010\u03baB signaling pathways in obesity\u2010related asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reticuline alleviates airway inflammation in obesity\u2010related asthma by inactivating the JAK2\/STAT3\/SOCS3 and p38 MAPK\/NF\u2010\u03baB signaling pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.13729","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T02:48:56Z","timestamp":1705718936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Anti\u2010inflammatory effects of reticuline on the JAK2\/STAT3\/SOCS3 and p38 MAPK\/NF\u2010\u03baB signaling pathway in a mouse model of obesity\u2010associated asthma"],"prefix":"10.1111","volume":"18","author":[{"given":"Xiaojiang","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital of North Sichuan Medical College  Nanchong 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