{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:46:12Z","timestamp":1791377172925,"version":"4.3.2"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n Biofilm formation is an important virulence factor of\n \n Acinetobacter baumannii<\/jats:italic>\n <\/jats:styled-content>\n . Here, we examined the biofilm formation of archived\n \n A. baumannii<\/jats:italic>\n <\/jats:styled-content>\n causing ventilator\u2010associated pneumonia (VAP).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighteen and twenty isolates of\n \n A. baumannii<\/jats:italic>\n <\/jats:styled-content>\n causing bacteremic pneumonia and non\u2010bacteremic pneumonia were included, respectively. Antimicrobial susceptibility testing was performed by broth microdilution method, while biofilm formation was evaluated by microtiter dish biofilm formation assay.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All 38 isolates were still susceptible to colistin and tigecycline, whereas almost all isolates were non\u2010susceptible (intermediate to resistant) to several antimicrobial agents, especially ceftriaxone and cefotaxime. Approximately, 44% of bacteremic isolates and 50% of non\u2010bacteremic isolates were classified as carbapenem\u2010resistant\n \n A. baumannii<\/jats:italic>\n <\/jats:styled-content>\n (CRAB). Biofilm formation was detected in 42% of the studied isolates. Bacteremia among the patients infected with biofilm\u2010producing isolates was significantly higher than in those infected with non\u2010biofilm\u2010producing isolates. The antimicrobial susceptibilities of\n \n A. baumannii<\/jats:italic>\n <\/jats:styled-content>\n with biofilm formation were lower than those without biofilm formation, but the differences did not have statistical significance. The patients infected with non\u2010biofilm\u2010producing isolates had good clinical and non\u2010clinical outcomes than those infected with biofilm\u2010producing isolates. The survival rate of patients diagnosed with VAP due to biofilm\u2010producing\n \n A. baumannii<\/jats:italic>\n <\/jats:styled-content>\n was lower than in those patients diagnosed with VAP due to non\u2010biofilm\u2010producing isolates.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Biofilm formation of\n \n A. baumannii<\/jats:italic>\n <\/jats:styled-content>\n causing VAP was associated with antimicrobial resistance and bacteremia as well as unfavorable clinical outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/crj.13732","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T03:04:45Z","timestamp":1705028685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of biofilm formation, antimicrobial resistance, clinical characteristics, and clinical outcomes among\n \n Acinetobacter baumannii<\/i>\n <\/scp>\n isolates from patients with ventilator\u2010associated pneumonia"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6999-5534","authenticated-orcid":false,"given":"Arnon","family":"Chukamnerd","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niwat","family":"Saipetch","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamonnut","family":"Singkhamanan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natnicha","family":"Ingviya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-9263","authenticated-orcid":false,"given":"Nawaporn","family":"Assanangkornchai","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komwit","family":"Surachat","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine Prince of Songkla University Hat Yai Thailand"},{"name":"Translational Medicine Research Center, Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarunyou","family":"Chusri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2016.02.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058\u201007"},{"key":"e_1_2_10_4_1","unstructured":"CDC.Antibiotic resistance threats in the United States 2019 (2019 AR Threats Report). 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