{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:12:30Z","timestamp":1781712750482,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lambert\u2013Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic neurological syndrome of the neuromuscular transmission. The symptoms often progress slowly and can be misdiagnosed in early stage. Seropositive SOX\u20101 antibodies are support for the diagnosis of LEMS and have high specificity for small cell lung cancer (SCLC). In this paper, we report a case of a 56\u2010year\u2010old man with smoking history who was admitted to hospital with progressive muscle weakness of the proximal legs. LEMS was diagnosed by repetitive nerve stimulation (RNS) testing and seropositive SOX\u20101 antibodies. Primary screening with chest computed tomography (CT) and integrated PET\/CT did not reveal any tumor. After continuous follow\u2010up, SCLC was found by chest CT and confirmed with pathological examination 10\u00a0months after the diagnosis of LEMS. Long\u2010term follow\u2010up and screening for occult SCLC in LEMS patients with positive SOX\u20101 antibodies are very important.<\/jats:p>","DOI":"10.1111\/crj.13740","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T08:58:17Z","timestamp":1710752297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SOX\u20101 antibodies positive Lambert\u2013Eaton myasthenic syndrome with occult small cell lung cancer: A case report"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1275-5420","authenticated-orcid":false,"given":"Liming","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology Hebei Chest Hospital  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology Hebei Chest Hospital  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology Hebei Chest Hospital  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology Hebei Chest Hospital  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pathology Hebei Chest Hospital  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Hebei Chest Hospital  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00297\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(11)70245\u20109"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DNND.S192588"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010017\u20108541\u20109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3912376"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.01.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010022\u201011523\u2010y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.6169"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2020.16.4.530"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000281663.81079.24"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21785"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13512"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.01.015"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5133"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12071542"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S369908"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00517\u20101"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:37:16Z","timestamp":1722299836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/crj.13740"],"URL":"https:\/\/doi.org\/10.1111\/crj.13740","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13740"}}