{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:38:54Z","timestamp":1792143534024,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Histiocytic sarcoma is an aggressive haematopoietic malignancy accounting for less than 1% of haematolymphoid neoplasms with a diagnosis based on morphology and immunophenotype of tissue biopsies with a very poor prognosis. Here, we report a 45\u2010year\u2010old man who was diagnosed with primary pulmonary histiocytic sarcoma with systemic metastases, with partial remission (PR) treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, but it relapsed soon after therapy above. Tests demonstrated that TMB was 21 Muts\/Mb PD\u2010L1 expression was 90% positive, and the disease has been well\u2010controlled over 3\u2009years using immune checkpoint inhibitors (nivolumab and pembrolizumab). Bioinformatic pan\u2010cancer analysis verified that there was the highest genetic alteration frequency of PD\u2010L1 in which amplification accounted for the majority of sarcoma tumour samples. Following that, we found that the genetic alteration of PD\u2010L1 was associated with poor prognosis in sarcoma patients in terms of overall survival (OS) (<jats:italic>p<\/jats:italic>\u2009=\u20091.51\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>), progress\u2010free survival (PFS) (<jats:italic>p<\/jats:italic>\u2009=\u20094.90\u2009\u00d7\u200910<jats:sup>\u22122<\/jats:sup>) and disease\u2010specific survival (DSS) (<jats:italic>p<\/jats:italic>\u2009=\u20094.90\u2009\u00d7\u200910<jats:sup>\u22122<\/jats:sup>). To our knowledge, this may be the first reported case with high PD\u2010L1 expression in primary pulmonary histiocytic sarcoma who may benefit from immunotherapy such as nivolumab and pembrolizumab significantly and safely.<\/jats:p>","DOI":"10.1111\/crj.13741","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:58:32Z","timestamp":1709809112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Primary pulmonary histiocytic sarcoma with high PD\u2010L1 expression benefited from immunotherapy: A case report and bioinformatic analysis"],"prefix":"10.1111","volume":"18","author":[{"given":"Yuanjie","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Jiangnan University Medical Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Jiangnan University Medical Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aonan","family":"Hong","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-0037","authenticated-orcid":false,"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Jiangnan University Medical Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.53.1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201010\u2010812495"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428191003699845"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012\u20100104\u2010RS"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000131541.95394.23"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1120009x.2020.1767477"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800346"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746\u20101596\u20102\u20107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.55.45"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010009\u20100801\u20103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/728260"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186932"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27491"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2022.2569"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010018\u20100200\u2010x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1511490"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.179150"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000000880"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.13741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:37:14Z","timestamp":1722299834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.13741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/crj.13741"],"URL":"https:\/\/doi.org\/10.1111\/crj.13741","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13741"}}